The effectiveness of using a molded sorbent: Modified polyvinylpyrrolidone for the combined treatment of chronic endometritis

Sergey V Barinov, С. В. Баринов, Yu. I. Tirskaya, Yuliya I Tirskaya, Anna V. Borisova, Lidiya G. Pyanova, Gian Carlo Di Renzo
International Journal of Gynecology & Obstetrics · 2021 · vol. 154(2) , pp. 277–284 · doi:10.1002/ijgo.13609 · PMID:33471361 · W3125054916
RCT OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This study found that combined therapy of a modified polyvinylpyrrolidone sorbent with antibiotics was more effective for chronic endometritis than antibiotics alone, reducing pathogens and pro-inflammatory cytokines.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To improve the management of patients with chronic endometritis (CE) by using a molded sorbent-modified by polyvinylpyrrolidone (FSMP). METHODS: This prospective study included 70 patients with CE divided into two groups: group 1 (n = 23) received traditional antibiotic therapy (from days 3 to 10 of the menstrual cycle); group 2 (n = 47), received antibiotics and FSMP was inserted from days 5 to 10. RESULTS: At the end of therapy, group 1 had massive growth of pathogenic microflora in 21.7%, moderate growth in 69.6%, and no growth in 8.7% of cases. In group 2, after combined therapy, massive growth was observed in 4.3%, moderate growth in 44.7%, and no growth in 51.0%. In group 2 after 5 days, serum levels of interleukin-1β (IL-1β) were 1.9 times, of IL-6 were 7.0 times, and of IL-8 and IL-1 receptor antagonist were 1.3 times lower than in group 1. In uterine cavity aspirates, IL-1β decreased around 4.8 times, IL-6 by 11.8 times, IL-8 by 3.2 times, tumor necrosis factor-α by 3.9 times, and IL-1 receptor antagonist by 2.1 times in comparison to group 1. CONCLUSION: Combined therapy of FSMP with antibiotics is more effective in treating CE, because it contributes to the almost complete elimination of pathogens and toxins from the uterine cavity, blocking the local pro-inflammatory cascade.

My notes (saved in your browser only)

Condition tags

disambig:endometritis

MeSH descriptors

Anti-Bacterial Agents Endometritis Povidone Adult Anti-Bacterial Agents Chronic Disease Cytokines Cytokines Endometritis Female Humans Interleukin-1beta Interleukin-1beta Menstrual Cycle Povidone Prospective Studies Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

References (22)

Source provenance

openalex
last seen: 2026-05-10T11:16:26.726288+00:00
pubmed
last seen: 2026-10-08T21:29:46.384990+00:00
License: CC0 · commercial use OK