GRIM19 downregulation-induced pyroptosis of macrophages through NLRP3 pathway in adenomyosis

Haoran Liu, Yue Zhao, Yang Yang, Wenqian Huang, Chao Lan, Lan Chao
Reproductive biomedicine online · 2021 · vol. 44(2) , pp. 211–219 · doi:10.1016/j.rbmo.2021.10.012 · PMID:34906422 · W3210874855
article OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated how GRIM19 downregulation triggers pyroptosis in macrophages via the NLRP3 pathway, contributing to adenomyosis pathology.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Apoptosis Regulatory Proteins NADH, NADPH Oxidoreductases NLR Family, Pyrin Domain-Containing 3 Protein NLR Family, Pyrin Domain-Containing 3 Protein NLR Family, Pyrin Domain-Containing 3 Protein Antibodies, Neutralizing Antibodies, Neutralizing Apoptosis Regulatory Proteins Down-Regulation Female Humans Macrophages Macrophages NADH, NADPH Oxidoreductases Pyroptosis

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References (35)

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europepmc
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License: CC0 · commercial use OK