The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. II: adenomyosis and macrophages

Kelton P Tremellen, Kelton Tremellen, Tremellen KP, Peter Russell, Russell P
Journal of Reproductive Immunology · 2011 · vol. 93(1) , pp. 58–63 · doi:10.1016/j.jri.2011.12.001 · PMID:22209314 · W2034819767
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This study investigated the distribution of immune cells and macrophages in the endometria of women experiencing recurrent reproductive failure, specifically focusing on cases of adenomyosis.

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Abstract

Adenomyosis, a condition usually associated with multiparity, is not generally seen as a cause of infertility. However, recent studies have reported a reduction in IVF implantation rates and a link with miscarriage, suggesting that adenomyosis may interfere with successful implantation. To investigate this hypothesis, the clinical records and laboratory results, which routinely include immunohistochemical examination of a late luteal phase endometrial biopsy for leukocytes, were retrospectively reviewed for 64 women with implantation failure and who previously had been screened for the presence of adenomyosis by pelvic MRI. The presence of either diffuse or "adenomyoma" type of adenomyosis was associated with a marked increase (p=0.004) in the density of macrophages and natural killer cells in the endometrial stroma, compared to those women with mild focal adenomyosis or no disease. These findings point to an immunological mechanism by which adenomyosis might interfere with successful embryo implantation.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Embryo Implantation Endometriosis Endometrium Infertility, Female Macrophages Embryo Implantation Embryo Implantation Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Humans Humans Infertility, Female Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (37)

Cited by (50)

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