Tom Holland

BACKGROUND: Endometriosis affects 190 million women and those assigned female at birth worldwide. For some, it is associated with debilitating chronic pelvic pain. Diagnosis of endometriosis is often achieved through diagnostic laparoscopy.…

BackgroundTubal ectopic pregnancies can cause significant morbidity or even death. Current treatment is with methotrexate or surgery. However, methotrexate treatment can fail in approximately 30% of women. Gefitinib, an epidermal growth fac…

Endometriosis is a common gynaecological problem, affecting approximately 5 per cent of women . The diagnosis can take many years and the condition can cause debilitating pain and infertility. The disease can be found in many sites througho…

Our study examined the impact of adenomyosis on the chance of clinical pregnancy after IVF and embryo transfer (IVF-ET). This was a prospective multicentre study from April 2013 to October 2015. We included 375 women with history of inferti…

To examine the impact of adenomyosis on outcome of in vitro fertilisation cycle and whether specific features of adenomyosis are associated with poor outcome. This is a prospective observational study in a population of women undergoing the…

To examine the impact of adenomyosis on obstetric outcome after in vitro fertilisation. This is a prospective observational study in a population of women undergoing their first IVF cycle in two London teaching hospitals between April 2013 …

The IDEA (International Deep Endometriosis Analysis group) statement is a consensus opinion on terms, definitions and measurements that may be used to describe the sonographic features of the different phenotypes of endometriosis. Currently…

OBJECTIVE: To investigate the association between the ultrasound features of adenomyosis and the severity of menstrual pain. METHODS: This was a prospective observational study set in the general gynecology clinic of a university teaching h…

Women presenting with typical symptoms of ureteric stones, such as renal colic, are referred to urologists for further examination and treatment. Atypical presentation includes pelvic pain which may be misdiagnosed as being of gynecological…

Ovarian endometriomas are classified as benign ovarian lesions. During pregnancy endometriomas may undergo major morphological changes which are referred to as ‘decidualisation'. Decidualised ovarian endometrioma may resemble malignant ovar…

STUDY QUESTION: Is there any benefit to including the routine examination by ultrasound of the bladder, ureters and kidneys of women with endometriosis? SUMMARY ANSWER: The benefit of examination of the complete urinary tract of women with …

Endometriosis is the presence of endometrial-like tissue outside the uterus, whichinduces a chronic, inflammatory reaction. It is a common and debilitatinggynaecological condition, which may cause severe pain, significant impairment ofquali…

BACKGROUND: Endometriosis is a common condition which causes pain and reduced fertility. Treatment can be difficult, especially for severe disease, and an accurate preoperative assessment would greatly help in the managment of these patient…

OBJECTIVE: To investigate the feasibility of identifying pelvic segments of normal ureters and measuring their size on standard transvaginal ultrasound examination. METHODS: This was a prospective observational study from June to July 2012…

STUDY QUESTION: What is the prevalence of adenomyosis in a population of women attending a general gynaecological clinic? SUMMARY ANSWER: Adenomyosis was present in 206 of 985 [20.9%; 95% confidence interval (CI): 18.5-23.6%] women included…

OBJECTIVE: To examine the reproducibility of assessment of severity of pelvic endometriosis by transvaginal sonography (TVS). METHODS: This was a prospective observational study conducted from August 2006 to July 2009 in two academic depart…

OBJECTIVE: The objective of this study was to examine the ability of preoperative transvaginal ultrasound (TVS) scanning to assess the severity of pelvic endometriosis. METHODS: Consecutive women with clinically suspected or proven pelvic e…

To assess if transvaginal ultrasound examination can accurately predict the severity of pelvic endometriosis. This would facilitate the triaging of patients with severe disease to specialist tertiary referral centres where their surgical ca…

OBJECTIVES: To assess the value of preoperative ultrasound examination in predicting the feasibility of intermediate-level laparoscopic surgery for benign adnexal masses. METHODS: Symptomatic women with a clinical or ultrasound diagnosis o…