Serum levels of cancer antigen 125 before hormone replacement therapy are not associated with clinical outcome of frozen embryo transfer in women with adenomyosis

Ling Huang, Yubin Li, Ming‐Hui Chen, Minghui Chen, Zengyan Wang, Canquan Zhou
The Journal of international medical research · 2021 · vol. 49(4) · doi:10.1177/03000605211005878 · PMID:33887984 · PMC8072100 · W3153546253
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Serum CA125 levels before hormone replacement therapy showed no association with the clinical outcomes of frozen embryo transfer in women with adenomyosis.

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Abstract

Aim This retrospective study aimed to evaluate the predictive value of serum cancer antigen 125 (CA125) levels before hormone replacement therapy on pregnancy outcomes in women with adenomyosis undergoing frozen embryo transfer. Methods A total of 509 women with adenomyosis were screened and 84 patients receiving a total of 114 cycles of frozen embryo transfer were included, based on the inclusion and exclusion criteria. Patients were divided into two groups based on their CA125 levels (≤ or >35 IU/mL) before hormone replacement therapy. The basic characteristics and main outcomes of the two groups were compared. Receiver operating characteristic curve and subgroup analyses were also conducted. Results There were no significant differences in clinical outcomes of frozen embryo transfer cycles in patients with different serum CA125 levels before hormone replacement therapy. Receiver operating characteristic curve analysis demonstrated that CA125 levels before hormone replacement therapy were not predictive of clinical pregnancy outcomes. Conclusions Serum CA125 levels before hormone replacement therapy are not associated with the clinical outcomes of frozen embryo transfer among women with adenomyosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis CA-125 Antigen Embryo Transfer Neoplasms CA-125 Antigen Female Hormone Replacement Therapy Humans Pregnancy Pregnancy Rate Retrospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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