Effects of short-course buserelin therapy on adenomyosis. A report of two cases.
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Two adenomyosis patients treated with a three-month GnRH-a nasal spray experienced symptom relief and conceived within six months of stopping treatment.
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Abstract
BACKGROUND: Hysterectomy and hysteroscopic endometrial ablation remain common treatment of symptomatic adenomyosis for women who have completed childbearing. However, for patients who wish to avoid surgery and in whom adenomyosis is suspected of causing infertility, repeated abortion or physical symptoms, medical treatment with gonadotropin-releasing hormone analogue (GnRH-a) should be considered. CASES: Two cases of documented adenomyosis were suspected of causing infertility; both were treated with a three-month course of GnRH-a via a nasal spray. Both patients experienced relief of symptoms and conceived within six months of the cessation of treatment. CONCLUSION: The efficacy and safety of a short course of GnRH-a treatment of adenomyosis may be considered in patients who take less time than others to achieve a significant reduction of uterine size and relief of symptoms and in those who develop side effects.
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- Serum levels of cancer antigen 125 before hormone replacement therapy are not associated with clinical outcome of frozen embryo transfer in women with adenomyosis 2021
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- Serum Levels of Cancer Antigen 125 before Hormone Replacement Therapy are not Associated with the Clinical Outcome of Frozen Embryo Transfer Cycles among Women with Adenomyosis 2019
- Faculty Opinions recommendation of Pregnancy rate in women with adenomyosis undergoing fresh or frozen embryo transfer cycles following gonadotropin-releasing hormone agonist treatment. 2019
- Faculty Opinions recommendation of The impact of adenomyosis on women's fertility. 2019
- Differential diagnosis of adenomyosis: the role of hysteroscopy and laparoscopy 2019
- The Investigation and Management of Adenomyosis in Women Who Wish to Improve or Preserve Fertility 2018
- High intensity focused ultrasound treatment of adenomyosis: a comparative study 2018
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- Myomas and Adenomyosis: Impact on Reproductive Outcome 2017
- Treatment options and reproductive outcome for adenomyosis-associated infertility 2017
- Clinical outcomes of infertility treatment for women with adenomyosis in Japan 2017
- Optimal uterine anatomy and physiology necessary for normal implantation and placentation 2016
- Pregnancy rate in women with adenomyosis undergoing fresh or frozen embryo transfer cycles following gonadotropin-releasing hormone agonist treatment 2016
- Pituitary suppression before frozen embryo transfer is beneficial for patients suffering from idiopathic repeated implantation failure 2016
- Effectiveness of treatment for infertility using clinical investigation of laparoscopy cytoreductive surgery combined with gestrinone in adenomyosis 2016
- Current Treatment for Adenomyosis 2015
- Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition 2015
- Adenomyosis and Its Effect on Reproductive Outcomes 2014
- Long-term pituitary downregulation before frozen embryo transfer could improve pregnancy outcomes in women with adenomyosis 2013
- Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes 2012
- Fertility outcome of infertile women with adenomyosis treated with the combination of a conservative microsurgical technique and GnRH agonist: Long-term follow-up in a series of nine patients 2012
- Adenomyosis and female fertility: A critical review of the evidence 2012
- Management of Adenomyosis in Subfertile Women and Pregnancy Outcome 2011
- Adenomyosis: Review of the Literature 2011
- Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI 2010
- Is the surgical approach beneficial to subfertile women with symptomatic extensive adenomyosis? 2008
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- Therapeutic options for adenomyosis: a review 2006
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- Endokrine operative Therapie der Adenomyosis 2004
- Adenomyosis in the baboon is associated with primary infertility 2004
- Adénocarcinome endométrioïde résultant de foyers d’adénomyose 2004
- Évolutions physiopathologiques, diagnostiques et thérapeutiques dans la prise en charge de l’adénomyose : revue de la littérature 2004
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- Uterine adenomyosis in the infertility clinic 2003
- Modified Reduction Surgery for Adenomyosis 2003
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