Effect of Adenomyosis on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Retrospective Cohort Study

Lei Yan, Lingling Ding, Rong Tang, Zi-Jiang Chen, Zi‐Jiang Chen
Gynecologic and obstetric investigation · 2013 · vol. 77(1) , pp. 14–18 · doi:10.1159/000355101 · PMID:24134923 · W2086645548
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This retrospective cohort study of 154 infertile women found that adenomyosis was associated with longer gonadotropin stimulation and significantly lower delivery rates following IVF/ICSI compared to controls.

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Abstract

AIMS: To study the effect of adenomyosis on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in infertile patients. METHODS: We performed a retrospective, database-searched cohort study based on 10,268 patients undergoing controlled ovarian hyperstimulation and IVF/ICSI between 2009 and 2011 in our unit. Adenomyosis was diagnosed by transvaginal ultrasound. A high-quality matched cohort study with strict inclusion criteria was conducted. We compared the basic characteristics and main IVF/ICSI outcomes between the two groups. RESULTS: We identified 83 patients with adenomyosis, of whom we included 77, and strictly matched them to 77 patients without adenomyosis. Higher day 3 estrogen levels and a longer duration of gonadotropin stimulation days were found in women with adenomyosis compared to control subjects. Patients with adenomyosis had a nonsignificant trend toward a lower clinical pregnancy rate and a higher miscarriage rate (p = 0.103 and 0.09, respectively). The delivery rate was significantly lower in the adenomyosis group in comparison to the matched controls (p = 0.022). CONCLUSIONS: Within the limitations of a retrospective study (albeit with a remarkably large number of observations), our results suggest that transvaginal ultrasound-diagnosed adenomyosis could have a negative impact on the main IVF/ICSI outcomes. Improving the diagnostic validity and scoring of disease severity in patients with adenomyosis is suggested.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Infertility, Female Sperm Injections, Intracytoplasmic Adenomyosis Adult Chi-Square Distribution Cohort Studies Female Humans Infertility, Female Infertility, Female Male Pregnancy Pregnancy Outcome Retrospective Studies Sperm Injections, Intracytoplasmic Sperm Injections, Intracytoplasmic

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References (15)

Cited by (26)

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