Asymptomatic adenomyosis and embryo implantation in IVF cycles

Laura Benaglia, Lucia Cardellicchio, Cardellicchio L, Marta Leonardi, M. Leonardi, Leonardi M, Sonia Faulisi, Faulisi S, Paolo Vercellini, Alessio Paffoni, Edgardo Somigliana, Luigi Fedele
Reproductive BioMedicine Online · 2014 · vol. 29(5) , pp. 606–611 · doi:10.1016/j.rbmo.2014.07.021 · PMID:25246118 · W2092630215
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This study investigated the impact of asymptomatic adenomyosis on embryo implantation rates in women undergoing in vitro fertilization (IVF).

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Abstract

Research on the effect of adenomyosis on the rate of success of IVF is controversial. Differences in study design, study power, criteria and instrument used to diagnose adenomyosis and choice of controls may explain these discrepancies. To establish whether embryo implantation is impaired in women with adenomyosis, women scheduled for IVF were prospectively evaluated for the presence of adenomyosis and whether this condition affected embryo implantation. Forty-nine women with adenomyosis diagnosed at transvaginal ultrasound with no abnormal uterine bleeding were recruited. They were matched for study period, age, day of embryo transfer and number of transferred embryos to 49 controls without the disease. In women with adenomyosis, 24 out of 76 embryos transferred implanted (32%); this occurred in 16 out of 76 (21%) in unaffected controls. The crude odds ratio of implantation in affected women was 1.73 (95% CI 0.83 to 3.60). The odds ratio adjusted for body mass index (the unique variable found to differ at univariate analysis) was 1.78 (95% CI 0.85 to 3.77). In conclusion, implantation rate is not impaired in asymptomatic women who are diagnosed with adenomyosis at transvaginal sonography. Affected women can be reassured about the effect of this condition on their chances of success.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Embryo Implantation Fertilization in Vitro Adenomyosis Adenomyosis Adult Case-Control Studies Embryo Transfer Female Fertilization in Vitro Humans Infertility, Female Infertility, Female Odds Ratio Pregnancy Pregnancy Outcome Pregnancy Rate Prospective Studies Sperm Injections, Intracytoplasmic

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