Evidence for estrogen synthesis in adenomyotic tissues

Yamamoto T, Takara Yamamoto, T. Yamamoto, T Noguchi, Noguchi T, Toshifumi Noguchi, Tamura T, T. Tamura, Takaya Tamura, J. Kitawaki, Kitawaki J, Jo Kitawaki, Okada H, H Okada, Hiroji Okada
American journal of obstetrics and gynecology · 1993 · vol. 169(3) , pp. 734–738 · doi:10.1016/0002-9378(93)90654-2 · PMID:8372890 · W2028723332
Lab / animal OA: closed CC0 ⤵ 87 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This paper provides evidence for the synthesis of estrogen within adenomyotic tissues.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To investigate steroidogenesis in eutopic and ectopic endometrial tissues in adenomyosis. STUDY DESIGN: Aromatase and estrone sulfatase activities were determined by anion-exchange resin column chromatography, thin-layer chromatography, and cocrystallization. The effects of danazol on the activity of these enzymes were also examined. Moreover, localization of aromatase in eutopic and ectopic endometrial tissues was immunohistochemically examined with antihuman placental aromatase cytochrome P-450 antibody. RESULTS: Aromatase and estrone sulfatase activities were detected in ectopic endometrium. The activity of these enzymes was significantly suppressed by danazol. In addition, aromatase was immunohistochemically detected in glandular cells of eutopic and ectopic endometrial tissues. CONCLUSIONS: The results suggest that estrogen is synthesized in the eutopic and ectopic endometrial tissues of women with uterine adenomyosis and that it may affect the growth of adenomyosis. Danazol suppressed synthesis of estrogen in vitro.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogens Neoplasms, Hormone-Dependent Uterine Neoplasms Adult Adult Aromatase Aromatase Aromatase Aromatase Inhibitors Aromatase Inhibitors Chromatography, Ion Exchange Chromatography, Ion Exchange Danazol Danazol Danazol Dose-Response Relationship, Drug Dose-Response Relationship, Drug Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (18)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-13T06:10:10.580696+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:59:31.578486+00:00
License: CC0 · commercial use OK