Characterization of periostin expression in human endometrium and endometriotic lesions

Liang Shen, Peishu Liu, Peihai Zhang, Xiaolei Zhang, Jing Cui
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2012 · vol. 28(10) , pp. 815–818 · doi:10.3109/09513590.2012.671387 · PMID:22471299 · W2105694561
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Periostin expression is increased in both eutopic and ectopic endometrium of women with endometriosis compared to normal endometrium, with cyclic variation observed in the eutopic stroma.

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Abstract

OBJECTIVE(S): To investigate the expression of periostin in the eutopic and ectopic endometrium of women diagnosed as endometriosis and evaluate the role of periostin in the pathogenesis of endometriosis. STUDY DESIGN: In this study, the expression of periostin was evaluated in the endometrial specimens from 35 women diagnosed as endometriosis and from 30 healthy women. To assess the presence and localization of periostin throughout the menstrual cycle in both eutopic and ectopic endometrium of women with endometriosis, microscopic evaluation was conducted. It was also subsequently compared with normal endometrium. RESULTS: In the eutopic and ectopic endometrium of women with endometriosis, immunoreactivities of periostin increased compared with those of normal endometrium. We also observed a cyclic variation in the eutopic stromal periostin immunoreactivity throughout their menstrual cycle because higher H score values were observed in the proliferative phase than those in the secretory phase. CONCLUSION(S): These findings indicated that periostin may be involved in the pathophysiology of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cell Adhesion Molecules Endometriosis Endometrium Menstrual Cycle Ovarian Cysts Adult Cell Adhesion Molecules Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Follicular Phase Follicular Phase Humans Immunohistochemistry Luteal Phase Luteal Phase

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References (22)

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