Differential regulation of Akt phosphorylation in endometriosis

Ozgur Cinar, Özgür Çınar, Seval Y, Yasemin Seval, Yeşim Hülya Uz, Yesim H Uz, Hakan Cakmak, Hakan Çakmak, Cakmak H, Murat Ulukuş, Murat Ulukus, Ulukus M, Umit A. Kayisli, Kayisli UA, Aydin Arici, Aydın Arıcı, Arici A
Reproductive BioMedicine Online · 2009 · vol. 19(6) , pp. 864–871 · doi:10.1016/j.rbmo.2009.10.001 · PMID:20031030 · W2056218682
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This study investigated how Akt phosphorylation is differentially regulated in endometriosis tissue compared to normal endometrial tissue.

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Abstract

Protein kinase B (PKB/Akt), a serine/threonine kinase, regulates the function of many cellular proteins involved in apoptosis and proliferation. It was postulated that there is a higher Akt activity in endometriosis compared with normal endometrium, and that oestrogen may be one of the factors responsible for the high Akt activation in endometriotic cells. Phospho-Akt (pAkt) concentrations in normal, eutopic and ectopic endometrial tissues were compared by immunohistochemistry, and a higher pAkt immunoreactivity was revealed in eutopic and ectopic endometrium compared with normal endometrium, in vivo. Higher Akt phosphorylation in stromal cells from eutopic endometrium was observed, when compared with normal, in vitro (P < 0.05). Akt phosphorylation was rapidly (2-10 min) stimulated when endometrial stromal cells from normal and endometriosis patients were treated with 17 beta-oestradiol. In endometrial stromal cells from the endometriosis group, ICI 182,780 (ICI, a specific oestrogen receptor antagonist) failed to antagonize the effect of oestradiol when combined with oestradiol, and revealed a stimulatory effect on Akt phosphorylation when given alone (P < 0.05). In conclusion, since Akt affects cell survival, it is suggested that increased Akt phosphorylation may be related to the altered apoptosis/proliferation harmony in endometriosis, and therefore Akt may play a critical role in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Proto-Oncogene Proteins c-akt Androstadienes Androstadienes Endometriosis Endometrium Endometrium Estradiol Estradiol Estradiol Female Fulvestrant Humans Phosphorylation Proto-Oncogene Proteins c-akt Wortmannin

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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