Curcumin and Endometriosis

Alexandre Vallée, Yves Lecarpentier
International journal of molecular sciences · 2020 · vol. 21(7) , pp. 2440 · doi:10.3390/ijms21072440 · PMID:32244563 · PMC7177778 · W3014780029
review OA: gold CC0 ⤵ 58 in-corpus citations
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This review summarizes curcumin's potential actions against endometriosis, focusing on its anti-inflammatory, antioxidant, anti-angiogenic, and anti-invasive properties.

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Abstract

Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.

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Condition tags

endometriosis

MeSH descriptors

Curcumin Endometriosis Animals Anti-Inflammatory Agents Anti-Inflammatory Agents Antioxidants Antioxidants Apoptosis Curcumin Endometriosis Female Humans Inflammation Oxidative Stress Peritoneal Cavity Reactive Oxygen Species

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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