Curcumin modulates oxidative stress to inhibit pyroptosis and improve the inflammatory microenvironment to treat endometriosis

Ding J, Jie Ding, Shanshan Mei, Mei S, Wang K, Kaili Wang, Cheng W, Wen Cheng, Shuai Sun, Sun S, Zhexin Ni, Ni Z, Wang X, Xiaoqiu Wang, Yu C, Chaoqin Yu
Genes & diseases · 2023 · vol. 11(3) , pp. 101053 · doi:10.1016/j.gendis.2023.06.022 · PMID:38292195 · PMC10827401 · W4385336738
article OA: gold CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-14 ⓘ

This study investigated how curcumin treatment impacts oxidative stress, pyroptosis, and the inflammatory environment to address endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-14 · read from full text ⓘ

The paper investigates how curcumin affects oxidative stress, pyroptosis, and the inflammatory microenvironment in the context of treating endometriosis, using a combination of experimental assays and analyses that include work involving clinical specimen collection and analysis. The key finding is that curcumin modulates oxidative stress, thereby inhibiting pyroptosis and improving the inflammatory microenvironment. The authors note limitations in the form of reliance on their experimental design and the specific specimen and experimental conditions used, with no additional limitations explicitly detailed in the provided text. This paper is centrally about endometriosis — it tests curcumin’s modulation of oxidative stress and pyroptosis to improve the inflammatory microenvironment as a treatment mechanism.

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Author

DJ, MSS, and WKL made equal contributions. DJ, MSS, and WKL designed and completed the experiments, completed the data analysis, and wrote the manuscript. CW and SS participated in the collection and analysis of clinical specimens. NZX participated in the supplementary experiments. WXQ and YCQ provided ideas for the experimental design and modified the manuscript to ensure the integrity of the entire experimental design. All authors participated in discussions of the experimental results and the final manuscript. We confirmed that all authors meet the ICMJE and agreed to submit the manuscript.

Funding

This work was supported by the National Natural Science Foundation of China (No. 82074206, 81774352, 81703874), the Shanghai 3-Year Action Plan for Traditional Chinese Medicine [ZY (2018-2020)-FWTX-1107], and the Medical Innovation Research Special Project of "Science and Technology Innovation Action Plan" of Shanghai Science and Technology Commission (China) (No. 21Y21920500).

Conflict

The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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