{"paper_id":"a5beae98-9e14-4a36-beda-5d84e6c401e8","body_text":"DJ, MSS, and WKL made equal contributions. DJ, MSS, and WKL designed and completed the experiments, completed the data analysis, and wrote the manuscript. CW and SS participated in the collection and analysis of clinical specimens. NZX participated in the supplementary experiments. WXQ and YCQ provided ideas for the experimental design and modified the manuscript to ensure the integrity of the entire experimental design. All authors participated in discussions of the experimental results and the final manuscript. We confirmed that all authors meet the ICMJE and agreed to submit the manuscript.\n\nThe authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.\n\nThis work was supported by the National Natural Science Foundation of China (No. 82074206, 81774352, 81703874), the Shanghai 3-Year Action Plan for Traditional Chinese Medicine [ZY (2018-2020)-FWTX-1107], and the Medical Innovation Research Special Project of \"Science and Technology Innovation Action Plan\" of Shanghai Science and Technology Commission (China) (No. 21Y21920500).","source_license":"CC0","license_restricted":false}