The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation
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Interstitial collagenase is expressed in human endometrium just before and during menstruation, and its expression is regulated by progesterone and estradiol.
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Abstract
Human endometrial tissue, sampled at different periods of the reproductive cycle, expressed interstitial collagenase mRNA, protein and activity only just before and during the menstrual period. This clear-cut correlation and the inhibition of collagenase expression by progesterone and oestradiol in tissue culture point to a pivotal role of this proteinase in the mechanism of menstrual tissue breakdown and bleeding.
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- Mechanisms of endometrial progesterone resistance 2011
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- Trimegestone differentially modulates the expression of matrix metalloproteinases in the endometrial stromal cell 2006
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- Focal Expression and Final Activity of Matrix Metalloproteinases May Explain Irregular Dysfunctional Endometrial Bleeding 2004
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- Hormonal regulation and localization of estrogen, progestin and androgen receptors in the endometrium of nonhuman primates: effects of progesterone receptor antagonists 2004
- Pathogenesis of Endometriosis 2003
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- Tissue integrity is essential for ectopic implantation of human endometrium in the chicken chorioallantoic membrane 2003
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- Transplantation of cultured explants of human endometrium into nude mice 2000
- 10.1016/s0246-1064(19)30021-0 2000
- Endometriosis, Endometrioma, and the Problem of Adhesions 2000
- A functional model for progestogen-induced breakthrough bleeding 2000
- Local cytokines induce differential expression of matrix metalloproteinases but not their tissue inhibitors in human endometrial fibroblasts 1999
- Metalloproteinases and tissue inhibitor of metalloproteinase 1 (TIMP-1) in endometrial flushings from pre- and post-menopausal women and from women with endometrial adenocarcinoma 1999
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- Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. 1997
- Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions 1997
- Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities 1997
- Focal cellular origin and regulation of interstitial collagenase (matrix metalloproteinase-1) are related to menstrual breakdown in the human endometrium 1996
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