Differential induction of matrix metalloproteinase 1 and 2 in ectopic endometrium
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⤵ 9 in-corpus citations
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This study investigated the differential induction of matrix metalloproteinase 1 and 2 in ectopic endometrium.
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Abstract
According to the transplantation theory, endometriosis develops from endometrial fragments that are retrogradely menstruated into the peritoneal cavity. In order to develop into endometriotic lesions, they have to connect to the vascular system by angiogenesis, probably involving matrix metalloproteinases (MMP) as key enzymes in extracellular matrix remodelling. A model of endometriosis using the chorioallantoic membrane (CAM) of chick embryos was established. Eutopic endometrium from healthy women was transferred to the CAM and cultivated ectopically for up to 3 days. Before transplantation and after 24, 48 and 72 h of culture on the CAM, total RNA was extracted and reverse transcribed. Human MMP-1 (interstitial collagenase) and MMP-2 (gelatinase A) mRNA expression was assessed by competitive PCR. Results were normalized to the content of human glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA. In eutopic endometrium, 0.29 amol MMP-1 mRNA and 0.42 fmol MMP-2 mRNA per fmol GAPDH mRNA were found. Relative MMP-1 mRNA concentrations increased strongly after culture on the CAM, while MMP-2 mRNA levels were nearly unaltered. This differential regulation suggests different roles of these enzymes in the angiogenesis of ectopic endometrial fragments and during the development of endometriosis.
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Cited by (9)
- Digestive system deep infiltrating endometriosis: What do we know 2023
- Serum kisspeptin levels in deep-infiltrating, ovarian, and superficial endometriosis: A prospective observational study 2022
- Menstruation Dysregulation and Endometriosis Development 2021
- Basic mechanisms of vascularization in endometriosis and their clinical implications 2018
- Are matrix metalloproteinases and their inhibitors reliable diagnosis biomarkers and attractive therapeutic targets in endometriosis? 2016
- Endometriosis, Angiogenesis and Tissue Factor 2012
- Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases 2010
- Difference in expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients with persistent ovarian cysts 2005
- Inhibiting MMP activity prevents the development of endometriosis in the chicken chorioallantoic membrane model 2004
SciLite annotations
organisms 4
lupinus microcarpus
noordeloos 2009062
human
human
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- europepmc
- last seen: 2026-08-11T06:11:44.160905+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:12:55.732728+00:00
- scilite
- last seen: 2026-05-18T04:57:49.680383+00:00
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