Localization of matrix metalloproteinase-2 in uterine endometrium and ectopic implants
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Endometriotic implants expressed significantly higher levels of latent gelatinase A compared to uterine endometrium, indicating a greater capacity for tissue invasion.
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Abstract
We performed an immunohistochemical study on paraffin-embedded tissues to evaluate the invasion pattern of endometriotic implants by determination of matrix metalloproteinase (gelatinase A) expression. Endometriotic tissues (n=32) and uterine endometria (n=18) of patients with endometriosis and uterine endometria of normal-menstruating women without endometriosis (n=11) were examined. Endometriotic tissues showed statistically significantly stronger staining compared with uterine endometria. However, we did not find differences in staining between uterine endometrium of women with endometriosis and normal controls. Compared to uterine endometrium, ectopic endometrium has a significantly higher capacity to produce the latent forms (72 kD) of gelatinase A. This leads to the conclusion that endometriotic implants express the protease enabling the invasion of surrounding tissue.
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- Are matrix metalloproteinases and their inhibitors reliable diagnosis biomarkers and attractive therapeutic targets in endometriosis? 2016
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- Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway 2015
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- Important Initiative Roles of CD44 and Tenascin in Sampson's Theory of the Pathogenesis and Development of Endometriosis 2013
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- Inhibiting MMP activity prevents the development of endometriosis in the chicken chorioallantoic membrane model 2004
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- Differential induction of matrix metalloproteinase 1 and 2 in ectopic endometrium 2003
- Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis 2003
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