Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells

The chemokine thymus-expressed chemokine (TECK), which regulates T-cell development and tissue-specific homing, has been identified as a potential contributor to the pathogenesis and progression of endometriosis. Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), an air pollutant, and estrogen also appear to be involved in endometriosis. Both endometrial stromal cells (ESCs) and the combination of 17β-estradiol and TCDD increase the secretion of TECK in the endometriosis-associated cells and promote the invasiveness of ESCs by increasing expression of matrix metalloproteinase (MMP)-2 and MMP-9. Anti-TECK neutralizing antibodies can effectively inhibit the invasiveness of ESCs and the expression of MMP-2 and MMP-9 in the cells. Interestingly, the expression of chemokine C receptor 9 (CCR9) and its ligand TECK increases significantly in the endometriotic milieu of patients with endometriosis. Therefore, the over-expressed TECK interacts with CCR9 on the ESCs in the endometriotic milieu, which may contribute to the onset and progression of endometriosis. This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 digital issues and online access to articles 111,21 € per year only 9,27 € per issue Buy this article - Purchase on SpringerLink - Instant access to the full article PDF. 39,95 € Prices may be subject to local taxes which are calculated during checkout Similar content being viewed by others

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This work was supported by the National Basic Research Program of China (2006CB944007, to DJ Li), the National and Shanghai Leading Academic Discipline Project (211XK22, to DJ Li) and the Program for Outstanding Medical Academic Leader of Shanghai (to DJ Li). The human peritoneal mesothelial cell line (HMrSV5) was generously provided by Professor Jian Yao (The First People’s Hospital, Shanghai, China) Author information Authors and Affiliations Rights and permissions About this article Cite this article Wang, Y., Yu, J., Luo, X. et al. Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells. Cell Mol Immunol 7, 51–60 (2010). https://doi.org/10.1038/cmi.2009.102 Received: Revised: Accepted: Published: Issue date: DOI: https://doi.org/10.1038/cmi.2009.102

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