Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium

Hye Won Chung, Chung HW, Ji Young Lee, Lee JY, Hye-Sung Moon, Moon HS, Hye Sung Moon, Sung Eun Hur, Hur SE, Mi Hye Park, Park MH, Yan Wen, Wen Y, Mary Lake Polan, Polan ML
Fertility and sterility · 2002 · vol. 78(4) , pp. 787–795 · doi:10.1016/s0015-0282(02)03322-8 · PMID:12372458 · W2085585495
article OA: bronze CC0 ⤵ 149 in-corpus citations
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This study investigated the expression of matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 in both ectopic and eutopic endometrial tissues.

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Abstract

ObjectiveTo investigate expression of matrix metalloproteinase-2 (MMP-2), membranous type 1 matrix metalloproteinase (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) in ectopic and eutopic endometrium from women with and without endometriosis throughout the menstrual cycle.DesignMolecular studies in human tissue.SettingReproductive immunology laboratory of a university medical center.Patient(s)Fifty-three premenopausal woman (23 with endometriosis and 30 without endometriosis) undergoing laparoscopic surgery. Endometrium and ectopic endometriosis tissue were obtained at the time of surgery.Main outcome measure(s)Messenger RNA and protein expression from eutopic and ectopic endometrium was analyzed by using quantitative competitive polymerase chain reaction, zymography, and Western blot assay.Result(s)Uterine endometrium from women with endometriosis expressed higher levels of MMP-2 and MT1-MMP and lower levels of TIMP-2 than did endometrium from normal women.Conclusion(s)Eutopic endometrium from patients with endometriosis may be more invasive and prone to peritoneal implantation because of greater expression of MMP-2 and MT1-MMP and lower expression of TIMP-2 messenger RNA, compared with endometrium from women without endometriosis. Thus, increased proteolytic activity may help to explain the invasive factors that result in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Matrix Metalloproteinase 2 Metalloendopeptidases Tissue Inhibitor of Metalloproteinase-2 Adult Blotting, Western Electrophoresis, Polyacrylamide Gel Endometriosis Endometriosis Endometrium Endometrium Female Humans Laparoscopy Matrix Metalloproteinase 2 Matrix Metalloproteinase 2 Matrix Metalloproteinases, Membrane-Associated Metalloendopeptidases

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