The DNA methylation status of genes encoding Matrix metalloproteinases and tissue inhibitors of Matrix metalloproteinases in endometriosis

Longying Tang, Yuqian Xiang, Yaohua Zhou, Jian Mu, Meiqing Zai, Qinghe Xing, Xinzhi Zhao, Lin He, Lei Wang, Xi Dong, Qiaoli Li
Molecular reproduction and development · 2017 · vol. 85(1) , pp. 17–25 · doi:10.1002/mrd.22931 · PMID:29266528 · W2770293922
article OA: closed CC0 ⤵ 10 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that DNA methylation in the promoter regions of MMP2, MMP3, MMP7, TIMP3, and TIMP4 genes was altered in endometriosis lesions, with MMP2 showing a negative correlation between methylation and transcript abundance.

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Abstract

Endometriosis is a benign disease, with malignant properties. A necessary step in the progression of endometriosis is tissue remodeling, which is coordinated by the activities of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs). This study evaluated the regulation of abnormal MMP and TIMP gene expression during endometriosis. Among the two genes families, promoter regions of MMP2, MMP3, MMP7, TIMP3, and TIMP4 were significantly altered in proliferative-phase endometriotic lesions compared to menstrual cycle-matched eutopic tissue from endometriosis-free women. In addition, a negative correlation was found between the DNA methylation status of the promoter region and transcript abundance of MMP2. Our findings suggest that changes in DNA methylation at the promoter region of MMP2 could underlie the changes in its expression in the ectopic endometria from patients with endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

DNA Methylation Endometriosis Matrix Metalloproteinase 2 Promoter Regions, Genetic DNA Methylation Endometriosis Endometriosis Female Gene Expression Regulation Gene Expression Regulation Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 3 Matrix Metalloproteinase 3 Matrix Metalloproteinase 7 Matrix Metalloproteinase 7 Menstrual Cycle Menstrual Cycle Promoter Regions, Genetic Tissue Inhibitor of Metalloproteinase-3

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (38)

Cited by (10)

Source provenance

europepmc
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License: CC0 · commercial use OK