Anti‐Endometriotic Effects of Pueraria Flower Extract  in Human Endometriotic Cells and Mice

Ji‐Hyun Kim, Ji-Hyun Kim, Jeong-Hwa Woo, Jeong‐Hwa Woo, Hye Jin Kim, Hye Mi Kim, Myung Sook Oh, Myung Oh, Dae Sik Jang, Jung‐Hye Choi, Jung-Hye Choi
Nutrients · 2017 · vol. 9(3) , pp. 212 · doi:10.3390/nu9030212 · PMID:28264481 · PMC5372875 · W2591940780
article OA: gold CC0 ⤵ 19 in-corpus citations
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Pueraria flower extract suppressed endometriotic cell adhesion and migration by reducing MMP-2/9 and activating ERK1/2, and inhibited lesion formation in a mouse model.

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Abstract

Pueraria flowers have been used as a vegetable and an ingredient for tea and jelly. In this study, we investigated the effects of Pueraria flower extract (PFE) on endometriosis, a common gynaecological disease characterised by local sterile inflammation of peritoneal cavity. PFE suppressed the adhesion of human endometriotic cells 11Z and 12Z to human mesothelial Met5A cells. In addition, PFE significantly inhibited the migration of 11Z and 12Z cells as shown by woundhealing and transwell migration assays. PFE reduced the protein and mRNA levels of matrix metalloproteinase (MMP)-2 and MMP-9 in endometriotic cells. Moreover, extracellular signalregulated kinase (ERK)1/2 was activated by PFE treatment, and an ERK1/2 inhibitor, PD98059, significantly inhibited PFE-inhibited cell migration in endometriotic cells. Furthermore, PFE significantly suppressed endometriotic lesion formation in a mouse model. These data suggest that Pueraria flower is a potential anti-endometriotic agent for the inhibition of endometriotic cell adhesion, migration, and MMP expression.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Flowers Plant Extracts Pueraria Animals Cell Adhesion Cell Adhesion Cell Line Cell Movement Cell Movement Cell Survival Cell Survival Down-Regulation Endometriosis Endometrium Endometrium Epithelial Cells Epithelial Cells Epithelial Cells

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