Chrysin leads to cell death in endometriosis by regulation of endoplasmic reticulum stress and cytosolic calcium level

Ryu S, Soomin Ryu, Bazer FW, Fuller W. Bazer, Whasun Lim, Gwonhwa Song
Journal of cellular physiology · 2018 · vol. 234(3) , pp. 2480–2490 · doi:10.1002/jcp.26770 · PMID:30302765 · W2898027937
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Chrysin induces apoptosis in human endometriotic cells by increasing cytosolic calcium and endoplasmic reticulum stress, while also inactivating the PI3K/AKT signaling pathway.

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Abstract

Chrysin is a natural compound derived from honey, propolis, or passion flowers and has many functional roles, such as antiinflammatory and antiangiogenesis effects. Although endometriosis is a benign gynecological disease, there is a need to identify the pathology and develop a therapy for endometriosis. Elucidating the biological mechanism of chrysin on endometriosis will improve the understanding of endometriosis. In this study, we confirmed the apoptotic effects of chrysin in human endometriotic cells using End1/E6E7 (endocervix-derived endometriotic cells) and VK2/E6E7 (vaginal mucosa-derived epithelial endometriotic cells). The results showed that chrysin suppressed the proliferation of endometriosis and induced programmed cell death through changing the cell cycle proportion and increasing the cytosolic calcium level and generation of reactive oxygen species. In addition, chrysin activated endoplasmic reticulum (ER) stress by stimulating the unfolded protein response proteins, especially the 78-kDa glucose-regulated protein-PRKR-like ER kinase (PERK)-eukaryotic translation initiation factor 2α (eIF2α) pathway in both endometriotic cell lines. Furthermore, chrysin inactivated the intracellular phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, also known as AKT) signaling pathway in a dose-dependent manner. Collectively, the results of this study indicated that chrysin induced programmed cell death by activating the ER stress response and inactivating the PI3K signaling pathways in human endometriotic cells.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endoplasmic Reticulum Stress Flavonoids Inflammation Angiogenesis Inhibitors Angiogenesis Inhibitors Anti-Inflammatory Agents Anti-Inflammatory Agents Apoptosis Apoptosis Calcium Calcium Cell Line Cell Proliferation Cell Proliferation Cytosol Cytosol eIF-2 Kinase eIF-2 Kinase Endometriosis

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