The role of endoplasmic reticulum stress in endometriosis

Hussein Riyadh Abdul Kareem Al-Hetty, Hussein Riyadh Abdul Kareem Al‐Hetty, Al-Hetty HRAK, Jabbar AD, Ahmed Darweesh Jabbar, Vladimir F Eremin, Eremin VF, Vladimir Eremin, Abeer Mohsen Jabbar, Jabbar AM, Abduladheem Turki Jalil, Ali G Al-Dulimi, Al-Dulimi AG, Hasanain A. J. Gharban, Gharban HAJ, Muhammad Usman Faryad Khan, Muhammad Usman Khan, Khan MUF, Saleh MM, Marwan Mahmood Saleh
Cell stress & chaperones · 2023 · vol. 28(2) , pp. 145–150 · doi:10.1007/s12192-023-01323-2 · PMID:36696012 · PMC10050460 · W4317934433
review OA: green CC0 ⤵ 6 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper investigates the role of endoplasmic reticulum stress in the development and progression of endometriosis.

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Abstract

Endometriosis is a chronic gynecologic disorder characterized by abnormal growth of endometrium-like tissues in the ectopic regions of the pelvic peritoneum. The pathophysiology of endometriosis is not completely understood; however, excessive endometrial cell proliferation together with resistance to apoptosis facilitates the migration, implantation, and survival of endometrial cells in the distant sites. Endoplasmic reticulum (ER) stress response (also called unfolded protein response) is a cellular defense mechanism triggered by ER stress. When severe enough, the so-called response initiates cell suicide, i.e., apoptosis. Therefore, therapeutic induction of ER stress in endometriotic cells could promote apoptosis and contribute to the management of disease. In this review, we discuss the pathogenic role of ER stress in endometriosis and the most recent findings regarding the induction of ER stress in connection with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (6)

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License: CC0 · commercial use OK