5,7‐Dimethoxyflavone induces apoptotic cell death in human endometriosis cell lines by activating the endoplasmic reticulum stress pathway

Wonhyoung Park, Min Young Park, Gwonhwa Song, Whasun Lim
Phytotherapy research : PTR · 2020 · vol. 34(9) , pp. 2275–2286 · doi:10.1002/ptr.6677 · PMID:32189411 · W3012486017
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5,7-Dimethoxyflavone triggers apoptotic cell death in human endometriosis cell lines by disrupting mitochondrial function and activating endoplasmic reticulum stress pathways.

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Abstract

Endometriosis is a reproductive disorder characterized by the dislocation of endometrial tissues. Approximately 5-20% of women at their reproductive age are diagnosed with endometriosis, which causes chronic pain and infertility. Here, we demonstrated that the bioactive flavonoid, 5,7-dimethoxyflavone (DMF), exhibited antiproliferative and apoptotic effects in VK2/E6E7 and End1/E6E7 cells which were established from vaginal and endocervical tissue taken from a premenopausal woman undergoing hysterectomy for endometriosis. DMF treatment significantly elevated DNA fragmentation resulting in apoptotic cell death in both cell lines. Furthermore, DMF induced loss of mitochondrial membrane potential, dysregulation of intracellular calcium level, and ROS production, which accelerate apoptosis. Additionally, DMF modulated the expression of the signaling molecules related to cell survival and endoplasmic reticulum stress in VK2/E6E7 and End1/E6E7 cells. Overall, DMF may ameliorate endometriosis and can be a potential alternative to hormonal and surgical therapy for endometriosis treatment.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Apoptosis Endometriosis Apoptosis Endometriosis Endoplasmic Reticulum Stress Endoplasmic Reticulum Stress Female Flavonoids Flavonoids Flavonoids Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (54)

Cited by (7)

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