Metabolic profile of follicular fluid in patients with ovarian endometriosis undergoing IVF: a pilot study

Luo T, Ting Luo, Wang M, Mengyao Wang, Ye He, He Y, Zhang M, Mengyuan Zhang, Liu B, Bin Liu, Wanqing Li, Li W, Fang Y, Youyan Fang, Wang W, Wanlu Wang, Xu Y, Yunyu Xu, Yunxia Cao, Cao Y, Wei Z, Zhaolian Wei
Reproductive BioMedicine Online · 2024 · vol. 49(2) , pp. 103912 · doi:10.1016/j.rbmo.2024.103912 · PMID:38810314 · W4392139093
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This pilot study identified 15 follicular fluid metabolites, including 8-hydroxy-2-deoxyguanosine, biotin, n-acetyl-L-methionine, and n-methylnicotinamide, that accurately diagnose ovarian endometriosis in patients undergoing IVF.

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Abstract

RESEARCH QUESTION: What are the metabolic characteristics of follicular fluid in patients with ovarian endometriosis undergoing IVF? DESIGN: This was an exploratory cohort study on endometriosis. In total, 19 infertile patients with ovarian endometriosis diagnosed by laparoscopy, and 23 controls matched in terms of age and body mass index (women with infertility due to male or tubal factors) were enrolled in this study. All patients underwent IVF treatment with a gonadotrophin-releasing hormone antagonist protocol, and follicular fluid was collected at oocyte retrieval. The metabolomics of follicular fluid samples was analysed using an ultra-high-performance liquid chromatography Orbitrap Exploris mass spectrometer (UHPLC-OE-MS). The best combination of biomarkers was selected by performing stepwise logistic regression analysis with backward elimination. RESULTS: Fifteen metabolites were identified as biomarkers associated with endometriosis. A final model containing 8-hydroxy-2-deoxyguanosine, biotin, n-acetyl-L-methionine and n-methylnicotinamide was constructed. Receiver operating characteristic analysis confirmed the value of these parameters in diagnosing endometriosis, with sensitivity of 94.7% and specificity of 95.7%. Enrichment analysis via the Kyoto Encyclopedia of Genes and Genome showed that 15 metabolites were enriched in eight metabolic pathways. CONCLUSION: Metabolomics based on UHPLC-OE-MS effectively characterized the metabolomics analysis of follicular fluid in patients with ovarian endometriosis. These findings may provide a new basis for better understanding of how diseases progress, and for the discovery of new biomarkers.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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