The inhibitory effect of 15-R-LXA4 on experimental endometriosis

Qionghua Chen, Zhou W, Weidong Zhou, Pu D, Demin Pu, Li Z, Zhiyong Li, Qian-Sheng Huang, Qiansheng Huang, Qing‐Xi Chen, Chen Q, Qingxi Chen
European journal of obstetrics, gynecology, and reproductive biology · 2009 · vol. 145(2) , pp. 200–204 · doi:10.1016/j.ejogrb.2009.05.015 · PMID:19523744 · W2164966838
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This paper investigates the inhibitory effect of 15-R-LXA4 on experimental endometriosis and its underlying mechanisms.

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Abstract

ObjectiveTo determine the pro-resolution actions of 15-R-LXA(4) (LXA(4)) on endometriotic lesions and on the expression of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the murine endometriosis model.Study designIn a prospective, placebo-controlled experimental study, endometriosis was induced in thirty BALB/c mice, and fifteen sham-operated mice served as negative controls. Among the thirty mice with induced endometriosis, fifteen were administered 15-R-LXA(4) and acted as study group (LXA(4) group) and the other fifteen were used as positive controls (EM group). Then all the mice were sacrificed and the endometriotic lesions were weighed. The mRNA and protein levels of IL-1beta and TNF-alpha in the peritoneal fluid were quantified by using real-time polymerase chain reaction (PCR) and enzyme-linked immunoabsorbent assay (ELISA).Result(s)Compared with the positive controls, 15-R-LXA(4) reduced the weight of the endometriotic lesions, decreased the concentrations of IL-1beta and TNF-alpha, and lowered the mRNA levels of IL-1beta and TNF-alpha in peritoneal fluid cells.Conclusion(s)These findings suggest that 15-R-LXA(4) inhibits the progression of endometriosis possibly by suppressing the gene and protein expression of IL-1beta and TNF-alpha.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Lipoxins Animals Ascitic Fluid Ascitic Fluid Endometriosis Estrous Cycle Estrous Cycle Female Interleukin-1beta Interleukin-1beta Interleukin-1beta Lipoxins Mice Mice, Inbred BALB C Prospective Studies RNA, Messenger RNA, Messenger Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha

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