Weidong Zhou

Ovarian endometriosis is a chronic inflammatory disease characterized by extensive tissue remodeling and fibrosis, which significantly impacts female reproductive health. This study demonstrates that ectopic endometrium (Ect) in patients wi…

Polycystic ovary syndrome (PCOS) is the most common and multifactorial endocrine disease among women of reproductive age. Aberrant folliculogenesis is a common pathological characteristic of PCOS, but the underlying molecular mechanism rema…

Purpose: This study was designed to reveal the molecular differences between granulosa cells (GCs) from patients with endometriosis and normal controls. Methods: RNA sequencing was performed on GCs from patients with EM-related infertility …

Extracellular vesicles (EVs) are newly identified as cell-to-cell communication mediators that carry and transfer various regulatory molecules. Recent studies have shown that EVs play important roles in normal physiology and pathological co…

Aim: To explore the circular RNA (circRNA) profile in cumulus cells from endometriosis-associated infertility patients. Methods: The expression of circRNAs was profiled by high-throughput sequencing. Sanger sequencing was performed to ident…

Research questionWhat is the expression pattern of microRNA (miRNA) in exosomes isolated from eutopic endometrial stromal cells (EuESC) of women with endometriosis-associated infertility?DesignSmall RNA sequencing was conducted in exosomes …

Endometriosis is an estrogen-dependent disease associated with pain and infertility. The objective of this study was to determine the expression of ZEB1 in endometriosis and its role in 17β-estradiol (E2)-induced epithelial-mesenchymal tran…

ObjectiveTo study the role of lipoxin A4 (LXA4) in endometriosis.DesignMolecular analysis in human samples and primary human endometriotic stromal cells (ESCs).SettingUniversity hospital.Patient(s)Forty-nine premenopausal women (30 patients…

BACKGROUND AND PURPOSE: Lipoxins can function as endogenous 'breaking signals' in inflammation and play important roles in the progression of endometriosis. In this study, we further investigated the molecular mechanism by which lipoxin A4 …

Endometriosis, an oestrogen-dependent disorder, is related to inflammation, p38 Mitogen activated protein kinases (p38 MAPK) can be activated by sex hormone and inflammatory factors, which plays an important role in many cellular reactions …

ObjectiveTo examine the pro-resolution actions of 15-epi-lipoxin A(4) (LXA(4)) on endometriotic lesions, on the concentrations and activities of matrix metalloproteinases (MMP-2 and MMP-9) in murine endometriosis.DesignProspective, vehicle-…

ObjectiveTo determine the pro-resolution actions of 15-R-LXA(4) (LXA(4)) on endometriotic lesions and on the expression of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the murine endometriosis model.Study desi…