15-Epi-lipoxin A4 inhibits the progression of endometriosis in a murine model

Qiong-Hua Chen, Chen QH, Qionghua Chen, Zhou WD, Wei-Dong Zhou, Weidong Zhou, Pu DM, Demin Pu, De-Min Pu, Qiansheng Huang, Qian-Sheng Huang, Li Tian, Tian Li, Li T, Chen QX, Qing-Xi Chen, Qing‐Xi Chen
Fertility and sterility · 2009 · vol. 93(5) , pp. 1440–1447 · doi:10.1016/j.fertnstert.2009.01.107 · PMID:19268934 · W2059302153
article OA: bronze CC0 ⤵ 15 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

15-Epi-lipoxin A4 significantly reduced endometriotic lesion size and vascularization in a mouse model, indicating a potential therapeutic role in inhibiting endometriosis progression.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo examine the pro-resolution actions of 15-epi-lipoxin A(4) (LXA(4)) on endometriotic lesions, on the concentrations and activities of matrix metalloproteinases (MMP-2 and MMP-9) in murine endometriosis.DesignProspective, vehicle-controlled experimental study.SettingAnimal research facility.Animal(s)BALB/c mice.Intervention(s)Endometriosis (EM) was induced in 30 mice. Fifteen of them were administered LXA(4) for 24 days (LXA(4) group), whereas the other 15 served as a control group (EM group). Another 15 sham-operated mice (sham-operated group) were treated with vehicles.Main outcome measure(s)The weight of the endometriotic lesions was measured. The concentrations, mRNA, and activities of MMP-2 and MMP-9 were determined by enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, and gelatin zymography, respectively.Result(s)Compared with EM group, the weight of the endometriotic lesions was decreased, the concentrations of MMP-2 and MMP-9 dropped, the mRNA levels of MMP-2 and MMP-9 in the peritoneal fluid cells and the endometriotic lesions were reduced, and the activities of MMP-2 and MMP-9 were inhibited in the LXA(4) group.Conclusion(s)LXA(4) may inhibit the progression of endometriosis possibly by lowering the concentrations and the activities of MMP-2 and MMP-9.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents, Non-Steroidal Endometriosis Endometrium Lipoxins Animals Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Ascitic Fluid Ascitic Fluid Ascitic Fluid Disease Models, Animal Disease Progression Down-Regulation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (38)

Cited by (15)

Source provenance

europepmc
last seen: 2026-08-09T06:10:49.860119+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:11.755070+00:00
License: CC0 · commercial use OK