Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis

Cleophas M Kyama, Cleophas Kyama, Overbergh L, Lutgart Overbergh, Attila Mihalyi, Mihalyi A, Meuleman C, Christel Meuleman, Jason M. Mwenda, Mwenda JM, Chantal Mathieu, D'Hooghe TM, Thomas D’Hooghe, Thomas M D'Hooghe
Fertility and sterility · 2007 · vol. 89(2) , pp. 301–310 · doi:10.1016/j.fertnstert.2007.02.057 · PMID:17678915 · W2132196046
article OA: bronze CC0 ⤵ 126 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated the expression of aromatase, cytokines, and adhesion factors in the endometrium and peritoneum of women diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo examine messenger (m) RNA expression of aromatase, cytokines, and adhesion factors in women with and without endometriosis.DesignPatients with endometriosis were compared with control patients.SettingUniversity Hospital Gasthuisberg, Leuven, Belgium.Patient(s)A total of 35 patients who had laparoscopic surgery during the luteal phase (n = 20) or the menstrual phase (n = 15) were selected for this study based on cycle phase and presence/absence of endometriosis.Intervention(s)Tissues of endometrium and macroscopically normal peritoneum were collected during hysteroscopy and laparoscopic surgery, respectively, from 24 women with revised American Society for Reproductive Medicine stage (rASRM) stages I-II (n = 12) and III-IV (n = 12) endometriosis and 11 control patients with normal pelvic. Tissue samples were selected from a tissue bank, based on the phase of the cycle (menstrual or luteal) and the presence/absence of endometriosis.Main outcome measure(s)The mRNA levels of aromatase, vimentin, vascular cell adhesion molecule 1 (VCAM-1), alpha(V) and beta(3) integrins, interleukin (IL)-1 beta, regulated on activation normal T-cell expressed and secreted (RANTES), and monocyte chemotactic protein 1 (MCP-1) were evaluated using real-time reverse transcriptase polymerase chain reaction.Result(s)During menstrual phase, increased endometrial mRNA levels of alpha(V) integrin, combined alpha(V)beta(3) integrins, and increased peritoneal IL-1 beta mRNA levels--but decreased peritoneal MCP-1 mRNA levels--were observed in women with endometriosis compared with control subjects. During luteal phase, endometrial mRNA levels of IL-1 beta and RANTES were increased in women with endometriosis compared with control subjects. Endometrial aromatase mRNA expression was higher in women with endometriosis than in control subjects in combined phases. Women with endometriosis had increased peritoneal mRNA expression of RANTES and VCAM-1 during menstrual compared with luteal phase.Conclusion(s)Aberrant mRNA expression of aromatase, cytokines, and adhesion factors in endometrium and peritoneum suggests that both tissues are involved in the pathogenesis of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Aromatase Cell Adhesion Molecules Cytokines Endometriosis Endometrium Peritoneum Uterine Diseases Adult Aromatase Aromatase Cell Adhesion Molecules Cell Adhesion Molecules Chemokine CCL5 Chemokine CCL5 Chemokine CCL5 Cytokines Cytokines Endometriosis Endometriosis Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (48)

Cited by (50)

Source provenance

europepmc
last seen: 2026-07-31T06:09:14.520117+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:54.534439+00:00
License: CC0 · commercial use OK