Gamma-Synuclein Levels Are Elevated in Peritoneal Fluid of Patients with Endometriosis

Noémi Csibi, Réka Brubel, Noémi Dobó, Katalin Viola Mészáros, Katalin Mészáros, Attila Molvarec, Péter Lukovich, János Rigó, Attila Bokor, Attila Z Bokor
Medical science monitor : international medical journal of experimental and clinical research · 2020 · vol. 26 , pp. e922137 · doi:10.12659/msm.922137 · PMID:32393729 · PMC7243616 · W3013433441
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Gamma-synuclein levels were found to be significantly higher in the peritoneal fluid of endometriosis patients compared to disease-free controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study measured gamma-synuclein (SNCG) levels in peritoneal fluid and plasma from 45 consecutive female patients with no endometriosis (n=15), minimal–mild endometriosis (n=15), or moderate–severe endometriosis (n=15), using enzyme-linked immunosorbent assay. SNCG was significantly higher in peritoneal fluid of patients with endometriosis versus disease-free controls (1.2-fold; p=0.04), while plasma SNCG did not differ significantly (p=0.086). A key limitation noted is the unexpected detection of SNCG in peritoneal fluid even in the disease-free control group, reflecting conflicting findings about SNCG expression in healthy tissues. This paper is centrally about endometriosis — it reports elevated gamma-synuclein levels in the peritoneal fluid of patients with endometriosis and examines its potential role in disease formation/progression.

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Abstract

BACKGROUND The role of gamma-synuclein (SNCG) has been widely examined in malignant conditions due to its possible role in disease progression, but very little information is available on its theoretical function on endometriosis formation. MATERIAL AND METHODS Between January 2016 and December 2016, we collected peritoneal fluid and plasma samples from 45 consecutive female patients, of which 15 were without endometriosis, 15 had minimal to mild endometriosis, and 15 had moderate to severe endometriosis. The statistical power was 0.98. We evaluated SNCG levels in the peritoneal fluid and plasma of patients diagnosed with endometriosis, and we compared them with the levels obtained from disease-free control subjects by using enzyme-linked immunosorbent assay. RESULTS SNCG levels were statistically significantly (1.2-fold) higher in the peritoneal fluid of patients with endometriosis compared to controls (p=0.04). We did not find a significant difference between SNCG levels in the plasma of our endometriosis patients and the control group (p=0.086). However, despite previous data showing very limited expression of SNCG in healthy tissues, we found SNCG in the peritoneal fluid of all of the patients in our healthy control group. CONCLUSIONS Levels of SNCG were statistically significantly higher in the peritoneal fluid of patients with endometriosis compared to disease-free controls, which may indicate its possible role the formation and progression of the disease. Moreover, its biological function should be further investigated due to the conflicting results concerning its expression in healthy tissues.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis gamma-Synuclein Adult Ascitic Fluid Ascitic Fluid Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female gamma-Synuclein gamma-Synuclein Humans Plasma Plasma

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