The risk of extra-ovarian malignancies among women with endometriosis: A systematic literature review and meta-analysis

S Gandini, Sara Gandini, Matteo Lazzeroni, M Lazzeroni, F A Peccatori, Peccatori FA, Fedro A. Peccatori, B Bendinelli, Bendinelli B, Benedetta Bendinelli, Calogero Saieva, C Saieva, Palli D, Domenico Palli, D Palli, G Masala, Giovanna Masala, Saverio Caini, S Caini
Critical reviews in oncology/hematology · 2019 · vol. 134 , pp. 72–81 · doi:10.1016/j.critrevonc.2018.12.009 · PMID:30771877 · W2909313321
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This systematic review and meta-analysis analyzed existing literature to assess the association between endometriosis and the risk of developing malignancies outside of the ovaries.

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Abstract

We conducted a meta-analysis of studies reporting on the risk of extra-ovarian malignancies among women with endometriosis. Summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We explored causes of between-studies heterogeneity and assessed the presence of publication bias. We included 32 studies published between 1989 and 2018. We found an increased risk of endometrial (SRR 1.38, 95%CI 1.10-1.74) and thyroid cancer (SRR 1.38, 95%CI 1.17-1.63), and inverse association with cervical cancer (SRR 0.78, 95%CI 0.60-0.95). No association emerged for breast cancer (SRR 1.04, 95%CI 0.99-1.09) and melanoma (SRR 1.31, 95%CI 0.86-1.96). Between-study heterogeneity was large for breast and endometrial cancer and melanoma. Associations were generally stronger in case-control, cross-sectional, and cohort studies with internal control group, compared to cohort studies with external control group. No indication for publication bias was found. Our conclusions need to be confirmed in properly designed cohort studies with clinical confirmation of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Breast Neoplasms Endometriosis Melanoma Breast Neoplasms Endometriosis Female Humans Melanoma Risk Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (42)

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