Reproductive Factors and Melanoma of the Skin Among Women

Grace Wyshak, G Wyshak, Rose E. Frisch, R E Frisch, Nile L. Albright, N L Albright, T E Albright, I Schiff, Isaac Schife
International journal of dermatology · 1989 · vol. 28(8) , pp. 527–530 · doi:10.1111/j.1365-4362.1989.tb04606.x · PMID:2583891 · W2093409983
article OA: closed CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that women with melanoma had a higher risk of reproductive disorders and fewer pregnancies, and confirmed associations with red hair.

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Abstract

A higher risk of reproductive system disorders, (which include benign tumors, endometriosis, dilation and curettage, hysterectomy, and other disorders requiring gynecologic biopsies) exist among women with cutaneous melanoma as compared to women with skin cancers: The odds ratio (OR) is 3.2, 95% confidence limits (1.0, 10.1), p = 0.049; as compared to a random sample of women with no melanoma or skin cancers, the OR is 3.9, 95% confidence limits (1.2, 12.4), p = 0.021. Confirming the observations of others, the authors found that melanoma was associated with red hair. The data also confirmed the finding that melanoma is associated with significantly fewer pregnancies. The mean numbers of pregnancies in the melanoma group is 1.83 +/- 1.6 (mean and standard deviation) compared to 2.99 +/- 1.9 in the skin cancer group and 2.93 +/- 1.9 in the random sample (p less than or equal to 0.05).

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Condition tags

endometriosis

MeSH descriptors

Genital Diseases, Female Genital Neoplasms, Female Melanoma Skin Neoplasms Analysis of Variance Biopsy Female Genital Diseases, Female Genital Diseases, Female Genital Neoplasms, Female Genital Neoplasms, Female Hair Color Humans Hysterectomy Melanoma Middle Aged Parity Pregnancy Risk Factors Skin Neoplasms

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References (10)

Cited by (13)

Source provenance

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