Incidence and Estimated Prevalence of Endometriosis and Adenomyosis in Northeast Italy: A Data Linkage Study

Caterina Morassutto, Lorenzo Monasta, Giuseppe Ricci, Fabio Barbone, Luca Ronfani
PloS one · 2016 · vol. 11(4) , pp. e0154227 · doi:10.1371/journal.pone.0154227 · PMID:27101396 · W2341654050
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study calculated the incidence and prevalence of endometriosis and adenomyosis in Northeast Italy from 2011-2013, finding a 0.14% incidence and an estimated 2.00% prevalence, with adenomyosis increasingly prevalent after age 50.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This population-based data linkage study used Friuli Venezia Giulia’s centralized health records (hospital discharge and anatomic pathology) to estimate incidence and prevalence of endometriosis and adenomyosis from new diagnoses made between 2011–2013 among women aged 15–83, applying “gold standard” requirements (laparoscopy ± histology for endometriosis; hysterectomy for adenomyosis) and excluding women diagnosed in the prior 10 years. Across 15–50-year-olds, the crude incidence of jointly considered endometriosis and adenomyosis was 0.14% (0.09% when restricted to histologically verified cases), with adenomyosis accounting for 28% of diagnoses and incidence peaking at ages 31–35 for endometriosis and 46–50 for adenomyosis. Prevalence was estimated from incidence under assumptions about chronicity and postmenopausal decline, yielding a jointly considered prevalence of 2.00% (1.82% endometriosis; 0.17% adenomyosis). This paper is centrally about endometriosis and adenomyosis — reporting incidence and estimated prevalence in Northeast Italy using linked administrative health and pathology data.

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Abstract

Despite being quite frequent and having serious implications in terms of symptomatology and fertility, data on incidence and prevalence of endometriosis and adenomyosis following gold standard definitions are dramatically lacking. The average time from onset of symptoms to diagnosis in industrialized countries still ranges from five to ten years. Using the regional centralized data linkage system, we calculated incidence and prevalence of endometriosis and adenomyosis in the female population of Friuli Venezia Giulia region, Italy, for the years 2011-2013. Cases were defined as new diagnoses from hospital discharge records, following procedures allowing direct visualization for endometriosis and hysterectomy for adenomyosis, with or without histological confirmation. Diagnoses were considered "new" after verifying women had not been diagnosed in the previous ten years. Incidence of endometriosis and adenomyosis in women aged 15-50 years is 0.14%. Prevalence, estimated from incidence, is 2.00%. Adenomyosis, representing 28% of all diagnoses, becomes increasingly prevalent after the age of 50 years. Our results shows how the study of both endometriosis and adenomyosis should not be limited to women of premenopausal age. Further efforts are needed to sensitize women and health professional, and to find new data linkage possibilities to identify undiagnosed cases.

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Condition tags

mesh:D004715endometriosisadenomyosis

MeSH descriptors

Adenomyosis Endometriosis Information Storage and Retrieval Registries Adenomyosis Adenomyosis Adolescent Adult Aged Age Factors Endometriosis Endometriosis Female Humans Incidence Information Storage and Retrieval Italy Italy Middle Aged Prevalence

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