The burden of endometriosis on quality of life in Danish blood donors

Lisette J. A. Kogelman, Dorte Rytter, Lone Hummelshøj, Karina Ejgaard Hansen, Kirk, Ulrik Bak, Juliane Lyng Beauchamp, Julie Beauchamp, Jakob Thaning Bay, Mie Topholm Bruun, Nanna Brøns, Christian Erikstrup, Bitten Aagaard, Bertram Kjerulff, Christina Mikkelsen, Susan Mikkelsen, Sisse Rye Ostrowski, Ole Birger Pedersen, Erik Sørensen, Henrik Ullum, Anne Karmisholt Grosen, Christian Lodberg Hvas, Valgerður Steinthórsdóttir, Kāri Stefánsson, Karina Banasik, Palle Duun Rohde, Henriette Svarre Nielsen, Mette Nyegaard
In: Research Square · 2025 · doi:10.21203/rs.3.rs-6620337/v1 · W4411066869
preprint OA: green CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Women with endometriosis experienced conception challenges, gastrointestinal and sleep disturbances, and lower mental health scores compared to controls, with shared genetic pathways suggested for gastrointestinal symptoms.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This study used questionnaire and registry data from 953 Danish women with clinically diagnosed endometriosis and 23,652 age-matched female blood-donor controls in the Danish Blood Donor Study, and tested associations between endometriosis and 37 potential comorbidities affecting quality of life, including conception, gastrointestinal symptoms, sleep patterns, and mental health. Using genome-wide polygenic scores (PGS) for endometriosis, the authors found that genetic endometriosis burden predicted having an endometriosis diagnosis and that gastrointestinal symptoms were also associated with the endometriosis PGS, suggesting shared genetic pathways. As a caveat, the paper notes that participants were blood donors and diagnoses were based on registry codes (not necessarily surgical/histologic verification), and comorbidities were measured through self-reported questionnaires at one timepoint. This paper is centrally about endometriosis — it links endometriosis diagnosis and endometriosis polygenic genetic burden to quality-of-life comorbidities in Danish blood donors.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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