The risk of endometriosis by early menarche is recently increased: a meta-analysis of literature published from 2000 to 2020

Mei-Yin Lu, Jia-Li Niu, Jiali Niu, Bin Liu
Archives of gynecology and obstetrics · 2022 · vol. 307(1) , pp. 59–69 · doi:10.1007/s00404-022-06541-0 · PMID:35377041 · W4225758411
review OA: closed CC0 ⤵ 17 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This meta-analysis of 16 studies from 2000-2020 found early menarche (<12 years) is associated with increased endometriosis risk, particularly in low-income countries and in studies initiated after 2000.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This meta-analysis examined whether early age at menarche (<12 years) is associated with endometriosis risk, synthesizing 16 studies published from 2000–2020 (searches in PubMed, Medline, and Embase) and using random-effects models with stratified analyses by country, study start year, study type (case–control vs cohort), and quality (Newcastle–Ottawa scale). The pooled results showed early menarche was associated with a significantly increased risk of endometriosis (OR 1.34, 95% CI 1.16–1.54) but with high heterogeneity (I²=72%). Stratification indicated a more noticeable association in studies started after 2000 and in low-income countries, and meta-regression supported these patterns (P<0.1), while no differences were seen by study type or NOS score. The paper concludes that the risk relationship appears to be increasing and calls for large-scale studies; This paper is centrally about endometriosis — it quantifies how early menarche is associated with endometriosis risk via a meta-analysis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Menarche Menarche Menarche Menarche Menarche Case-Control Studies Case-Control Studies Case-Control Studies Case-Control Studies Case-Control Studies Cohort Studies Cohort Studies Cohort Studies

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