Peritoneal bacteria contamination and endometriosis pathogenesis

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This paper reviews the bacterial contamination hypothesis suggesting that peritoneal bacteria play a role in the pathogenesis of endometriosis.

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This short article discusses the bacterial contamination hypothesis as it relates to endometriosis pathogenesis, framing peritoneal bacterial contamination as a potential contributor to disease development. It synthesizes concepts connecting the peritoneal/host microbiota with inflammatory and reproductive tract processes, drawing on prior literature on gut and genital microbiota and their proposed roles in endometriosis. A key limitation explicitly noted in the publication details is that the article does not report original human or animal studies performed by the authors. This paper is centrally about endometriosis — it focuses on how peritoneal bacterial contamination could be involved in endometriosis pathogenesis.

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References Yuan W, Wu Y, Chai X, Wu X (2022) The colonized microbiota composition in the peritoneal fluid in women with endometriosis. Arch Gynecol Obstet. https://doi.org/10.1007/s00404-021-06338-7 Huang L, Liu B, Liu Z, Feng W, Liu M, Wang Y (2021) Gut microbiota exceeds cervical microbiota for early diagnosis of endometriosis. Front Cell Infect Microbiol 11:788836 Salliss ME, Farland LV, Mahnert ND, Herbst-Kralovetz MM (2021) The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain. Hum Reprod Update 28:92–131 Khan KN, Fujishita A, Hiraki K, Kitajima M, Nakashima M, Fushiki S et al (2018) Bacterial contamination hypothesis: a new concept in endometriosis. Reprod Med Biol 17:125–133 Doroftei B, Ilie OD, Balmus IM, Ciobica A, Maftei R, Scripcariu I et al (2021) Molecular and clinical insights on the complex interaction between oxidative stress, apoptosis, and endobiota in the pathogenesis of endometriosis. Diagnostics (Basel) 11:1434 Jiang I, Yong PJ, Allaire C, Bedaiwy MA (2021) Intricate connections between the microbiota and endometriosis. Int J Mol Sci 22:5644 Funding None. Author information Authors and Affiliations Contributions CI: project development, data collection, manuscript writing, manuscript editing. NV: project development, data collection, manuscript writing. IDG: project development, data collection, manuscript writing, manuscript editing. Corresponding author Ethics declarations Conflict of interest Christos Iavazzo declares that he has no conflict of interest. Evelyn Eleni Minis declares that she has no conflict of interest. Ioannis D. Gkegkes declares that he has no conflict of interest. Also, the authors have full control of all primary data and agree to allow the Journal to review their data if requested. Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions About this article Cite this article Iavazzo, C., Vrachnis, N. & Gkegkes, I.D. Peritoneal bacteria contamination and endometriosis pathogenesis. Arch Gynecol Obstet 307, 221–222 (2023). https://doi.org/10.1007/s00404-022-06467-7 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00404-022-06467-7

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Ascitic Fluid Female Humans Peritoneum Peritoneum

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europepmc
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openalex
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