Unravelling the Complexity of Endometriosis: Insights into its Multifactorial Etiology and Clinical Management

Deepthi, Natarjan Muninathan, Arumugam Suresh, Kuppusam Baskaran, Aswathi
In: Journal of Advanced Zoology · 2023 · vol. 44(3) , pp. 345–359 · doi:10.17762/jaz.v44i3.628 · W4387484797
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This review examines the multifactorial etiology of endometriosis, including genetic, hormonal, immunological, and environmental factors, and discusses its current and emerging clinical management strategies.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper is a review examining endometriosis as a multifactorial disease, synthesizing current knowledge on genetic, hormonal, immunological, and environmental contributors to its etiology and pathogenesis. It discusses candidate genes and genetic variants, reviews immunological factors, and summarizes potential effects of environmental exposures such as toxins as well as diet and lifestyle. The article also outlines clinical management approaches, including existing treatments and emerging therapies, and emphasizes a multidisciplinary approach for diagnosis and care. This paper is centrally about endometriosis — it focuses on its multifactorial etiology and overview of clinical management.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a multifactorial disease characterized by the presence of endometrial-like tissue outside the uterus. The etiology and pathogenesis of endometriosis involve multiple factors, including genetic, hormonal, immunological, and environmental factors. This review article focuses on the multifactorial aspects of endometriosis and provides a comprehensive overview of the current knowledge in the field. The article discusses the genetic basis of endometriosis, highlighting the role of specific genes and genetic variants in the pathogenesis of the disease. It also reviews the immunological factors that contribute to the development and environmental factors such as toxins, diet, and lifestyle are also discussed concerning their potential impact on endometriosis. Finally, the article examines the clinical management of endometriosis, including current treatments and emerging therapies. In summary, this review article provides a comprehensive and up-to-date overview of the multifactorial aspects of endometriosis, highlighting the need for a multidisciplinary approach to the diagnosis and management of this complex disease.
Full text 1,628 characters · extracted from oa-doi-fallback · click to expand
Unravelling the Complexity of Endometriosis: Insights into its Multifactorial Etiology and Clinical Management DOI: https://doi.org/10.17762/jaz.v44i3.628Keywords: Endometriosis, inflammatory cytokines, Candidate genes, multifactorial diseasesAbstract Endometriosis is a multifactorial disease characterized by the presence of endometrial-like tissue outside the uterus. The etiology and pathogenesis of endometriosis involve multiple factors, including genetic, hormonal, immunological, and environmental factors. This review article focuses on the multifactorial aspects of endometriosis and provides a comprehensive overview of the current knowledge in the field. The article discusses the genetic basis of endometriosis, highlighting the role of specific genes and genetic variants in the pathogenesis of the disease. It also reviews the immunological factors that contribute to the development and environmental factors such as toxins, diet, and lifestyle are also discussed concerning their potential impact on endometriosis. Finally, the article examines the clinical management of endometriosis, including current treatments and emerging therapies. In summary, this review article provides a comprehensive and up-to-date overview of the multifactorial aspects of endometriosis, highlighting the need for a multidisciplinary approach to the diagnosis and management of this complex disease. Downloads Downloads Published Issue Section License Copyright (c) 2023 Deepthi, Natarjan Muninathan, Arumugam Suresh, Kuppusam Baskaran, Aswathi This work is licensed under a Creative Commons Attribution 4.0 International License.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK