Unravelling the Complexity of Endometriosis: Insights into its Multifactorial Etiology and Clinical Management

Deepthi, Natarjan Muninathan, Arumugam Suresh, Kuppusam Baskaran, Aswathi
In: Journal of Advanced Zoology · 2023 · vol. 44(3) , pp. 345–359 · doi:10.17762/jaz.v44i3.628 · W4387484797
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review examines the multifactorial etiology of endometriosis, including genetic, hormonal, immunological, and environmental factors, and discusses its current and emerging clinical management strategies.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper is a review examining endometriosis as a multifactorial disease, synthesizing current knowledge on genetic, hormonal, immunological, and environmental contributors to its etiology and pathogenesis. It discusses candidate genes and genetic variants, reviews immunological factors, and summarizes potential effects of environmental exposures such as toxins as well as diet and lifestyle. The article also outlines clinical management approaches, including existing treatments and emerging therapies, and emphasizes a multidisciplinary approach for diagnosis and care. This paper is centrally about endometriosis — it focuses on its multifactorial etiology and overview of clinical management.

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Abstract

Endometriosis is a multifactorial disease characterized by the presence of endometrial-like tissue outside the uterus. The etiology and pathogenesis of endometriosis involve multiple factors, including genetic, hormonal, immunological, and environmental factors. This review article focuses on the multifactorial aspects of endometriosis and provides a comprehensive overview of the current knowledge in the field. The article discusses the genetic basis of endometriosis, highlighting the role of specific genes and genetic variants in the pathogenesis of the disease. It also reviews the immunological factors that contribute to the development and environmental factors such as toxins, diet, and lifestyle are also discussed concerning their potential impact on endometriosis. Finally, the article examines the clinical management of endometriosis, including current treatments and emerging therapies. In summary, this review article provides a comprehensive and up-to-date overview of the multifactorial aspects of endometriosis, highlighting the need for a multidisciplinary approach to the diagnosis and management of this complex disease.

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endometriosis

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