Possible involvement of arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1 genes in the development of endometriosis

H Baranova, В. С. Баранов, M Canis, T Ivaschenko, E Albuisson, R Bothorishvilli, V Baranov, P Malet, M A Bruhat
Molecular human reproduction · 1999 · vol. 5(7) , pp. 636–641 · doi:10.1093/molehr/5.7.636 · PMID:10381818 · W2144048414
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This study investigated the association between NAT2, GSTM1, and GSTT1 gene polymorphisms and endometriosis, finding significant differences in NAT2 slow acetylator genotypes and GSTM1-deficient genotypes in patients compared to controls.

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Abstract

Wide inter-individual variation of expression of compound metabolic enzymes is determined by polymorphism and may predispose the development of diseases provoked by environmental factors. The combined analysis of phase II detoxification system genes: arylamine N-acetyltransferase 2 (NAT2), and glutathione S-transferases (GST) M1 and T1 was carried out in patients with minimal/mild (group I; n = 36) and moderate/severe endometriosis (group II; n = 29) and controls (n = 72) of French origin, using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The results show a significant difference between patients and controls with regard to NAT2 gene polymorphism (P < 0.05). This is mainly due to the high percentage of slow acetylator genotypes (SA) in patients compared with controls (60.0 versus 38.9%; P < 0.02) with a distinct preponderance in subjects with minimal/mild endometriosis (69.4%, P < 0.005) where there is a significantly elevated frequency of slow allele S1 (NAT2*5) (P = 0.05). Significantly increased proportions of GSTM1-deficient genotypes were found in both groups of patients, in comparison with the controls (75.0 and 79.3% versus 45.8%; P < 0. 0001). A preponderance of GSTT1-negative subjects among patients was also detected, but did not appear significant. We suggest the involvement of both NAT2 and GSTM1 detoxification system genes in the pathogenesis of endometriosis and the possible impact of NAT2 gene polymorphism in the development of different forms of this disease.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Arylamine N-Acetyltransferase Endometriosis Endometriosis Glutathione Transferase Polymorphism, Restriction Fragment Length Arylamine N-Acetyltransferase DNA DNA DNA Primers Endometriosis Endometriosis Endometrium Endometrium Female France Glutathione Transferase Humans Infertility, Female Infertility, Female Isoenzymes

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