Glutathione-S-transferase P1 gene polymorphism and susceptibility to endometriosis

Devrim Ertunç, D Ertunc, M Aban, Meral Aban, E C Tok, Ekrem C. Tok, Lülüfer Tamer, L Tamer, Mehtap Arslan, M Arslan, S Dilek
Human Reproduction · 2005 · vol. 20(8) , pp. 2157–2161 · doi:10.1093/humrep/dei053 · PMID:15878920 · W2134110886
article OA: closed CC0 ⤵ 14 in-corpus citations
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This case-control study found that the GSTP1 val/val genotype was significantly protective against endometriosis, while the ile/ile genotype showed a trend towards increased risk.

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Abstract

BACKGROUND: Glutathione-S-tranferase (GST) is the part of the key phase II detoxifying enzyme system. Many studies have investigated the role of GSTM1 and GSTT1 gene polymorphisms in endometriosis. Although GSTP1 was found to be one of the most abundant types of GST in genital system, there are insufficient data about the importance of the role of GSTP1 gene polymorphism in endometriosis. METHODS: This case-control study involved 150 patients with endometriosis and 150 controls. The frequency of GSTP1 single nucleotide polymorphisms was evaluated using PCR and melting curve analysis. RESULTS: The proportion of GSTP1 ile/ile tended to be higher in patients with endometriosis than control group, although the difference was not significant [odds ratio (OR)=1.53; 95% confidence interval (CI)=0.95-2.46]. In contrast, GSTP1 val/val was significantly higher in control patients and seems protective for endometriosis (OR=0.10; 95% CI=0.02-0.42). CONCLUSION: The results of this study suggest that GSTP1 polymorphism might modulate the risk of endometriosis with significantly decreased risk for GSTP1 val/val and marginally increased risk for GSTP1 ile/ile. Further studies on not only the disease processes but also normal distribution of the enzyme in female genital tract may provide better understanding about the role of GST types and their polymorphs in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Glutathione Transferase Isoenzymes Polymorphism, Single Nucleotide Adult Case-Control Studies Endometriosis Female Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Glutathione S-Transferase pi Glutathione Transferase Humans Isoenzymes Risk Factors

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