Glutathione-S-transferase P1 gene polymorphism and susceptibility to endometriosis

D Ertunc, Ertunc D, Devrim Ertunç, M Aban, Meral Aban, Aban M, Tok EC, E C Tok, Ekrem C. Tok, L Tamer, Lülüfer Tamer, Tamer L, Arslan M, M Arslan, Mehtap Arslan, S. Dilek, Dilek S
Human Reproduction · 2005 · vol. 20(8) , pp. 2157–2161 · doi:10.1093/humrep/dei053 · PMID:15878920 · W2134110886
Observational OA: closed CC0 ⤵ 14 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This case-control study found that the GSTP1 val/val genotype was significantly protective against endometriosis, while the ile/ile genotype showed a trend towards increased risk.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: Glutathione-S-tranferase (GST) is the part of the key phase II detoxifying enzyme system. Many studies have investigated the role of GSTM1 and GSTT1 gene polymorphisms in endometriosis. Although GSTP1 was found to be one of the most abundant types of GST in genital system, there are insufficient data about the importance of the role of GSTP1 gene polymorphism in endometriosis. METHODS: This case-control study involved 150 patients with endometriosis and 150 controls. The frequency of GSTP1 single nucleotide polymorphisms was evaluated using PCR and melting curve analysis. RESULTS: The proportion of GSTP1 ile/ile tended to be higher in patients with endometriosis than control group, although the difference was not significant [odds ratio (OR)=1.53; 95% confidence interval (CI)=0.95-2.46]. In contrast, GSTP1 val/val was significantly higher in control patients and seems protective for endometriosis (OR=0.10; 95% CI=0.02-0.42). CONCLUSION: The results of this study suggest that GSTP1 polymorphism might modulate the risk of endometriosis with significantly decreased risk for GSTP1 val/val and marginally increased risk for GSTP1 ile/ile. Further studies on not only the disease processes but also normal distribution of the enzyme in female genital tract may provide better understanding about the role of GST types and their polymorphs in endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Glutathione Transferase Isoenzymes Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Genetic Predisposition to Disease Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Genotype Glutathione S-Transferase pi

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (35)

Cited by (14)

Source provenance

europepmc
last seen: 2026-10-15T06:08:49.021275+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:03:11.681822+00:00
unpaywall
last seen: 2026-10-15T06:24:24.424788+00:00
License: CC0 · commercial use OK