Association of GSTP1 −313A/G polymorphisms and endometriosis risk: a meta-analysis of case–control studies

Xu Chen, Yulan Yan, Yan Y, Ping Li, Li P, Yang Z, Zheng Yang, Lingyan Qin, Qin L, Wuning Mo, Mo W
European journal of obstetrics, gynecology, and reproductive biology · 2013 · vol. 171(2) , pp. 362–367 · doi:10.1016/j.ejogrb.2013.10.005 · PMID:24183097 · W2049818094
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This meta-analysis investigated the association between GSTP1 -313A/G polymorphisms and endometriosis risk using case-control studies.

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Abstract

ObjectivesIn view of the controversies surrounding the association of glutathione S-transferases (GST) P1 with endometriosis, a meta-analysis of GSTP1 -313A/G polymorphism with endometriosis risk was performed.Study designThe relevant studies were identified through a search of PubMed, Excerpta Medica Database (Embase), Elsevier Science Direct and Chinese Biomedical Literature Database (CBM) until March 2013. The association between GSTP1 -313A/G polymorphism and endometriosis risk was pooled by odds ratios (ORs) together with their 95% confidence intervals (95% CIs).ResultsA total of eight case-control studies were eventually identified. We found that GSTP1-313A/G polymorphism was not associated with endometriosis risk in the overall population (A vs. G: OR=1.02, 95% CI=0.97-1.07, P=0.511; AA vs. GG: OR=1.02, 95% CI=0.98-1.06, P=0.359; GA vs. GG: OR=1.03, 95% CI=0.98-1.08, P=0.299; AA vs.Ga/ggOR=1.01, 95% CI=0.96-1.07, P=0.621; AA/GA vs. GG: OR=1.00, 95% CI=0.97-1.03, P=0.972). In the sub-group analysis based on ethnicity, a significant association was found in Caucasians under the recessive model (AA vs.Ga/ggOR=1.28, 95% CI=1.08-1.53, P=0.006).ConclusionsGSTP1 -313A/G polymorphism may not be associated with endometriosis risk, while the observed increase in risk of endometriosis may be due to small-study bias. Considering the limited sample size and ethnicity included in our meta-analysis, an updated meta-analysis will be urgently needed when further larger and well-designed studies are published.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Glutathione S-Transferase pi Asian People Asian People Case-Control Studies Endometriosis Female Genetic Predisposition to Disease Glutathione S-Transferase pi Humans Polymorphism, Single Nucleotide

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