Glutathione S- Transferase M1 in the Serum of Patients with Endometriosis

Zahra Sorkhoo
In: Journal of Molecular Biology Research · 2016 · vol. 6(1) , pp. 67 · doi:10.5539/jmbr.v6n1p67 · W2532888393
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This study found significantly reduced serum levels of Glutathione S-transferase M1 in women with endometriosis compared to healthy controls.

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This study investigated the role of Glutathione S-transferase M1 (GSTM1) in the pathophysiology of endometriosis by comparing serum levels between affected patients and healthy controls. Researchers measured total protein concentration and GSTM1 levels using biuret assays and enzyme-linked immunosorbent assays in blood samples from twenty women with endometriosis and twenty healthy individuals. The results indicated that while total protein concentrations remained within normal ranges for both groups, there was a statistically significant reduction in serum GSTM1 levels among the patients with endometriosis compared to the control group. This paper is centrally about endometriosis, specifically examining the association between reduced serum GSTM1 levels and the presence of the disease.

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Abstract

Endometriosis is a female disease with high incidence and unknown causes because of the presence of endometrial tissue outside of the uterine wall. Glutathione S- transferase (GSTs) is a key enzyme in phase I and II that catalyzes the conjugation of glutathione to genotoxic compounds. Glutathione S- transferase M1 (GSTM1) is a versatile enzyme that plays an important role in detoxification of carcinogenic metabolites. The aim of this study was to evaluate serum levels GSTM1 in patients with endometriosis. In this study, blood samples from 20 women with endometriosis and 20 healthy women were collected. The final concentration of protein in the blood of patients (TPC) and GSTM1 in serum by using "biuret" and enzyme-linked immunosorbent assay "(ELISA) were measured. It was shown that the level of total protein concentration all samples are within the normal range and no significant changes between the two groups were seen. Although significant reduction in serum levels GSTM1 was observed in patients with Endometriosis compared to the control group (P = 0.002). The results of this study showed that GSTM1 is involved pathophysiology of endometriosis.
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Glutathione S- Transferase M1 in the Serum of Patients with Endometriosis - Zahra Sorkhoo Abstract Endometriosis is a female disease with high incidence and unknown causes because of the presence of endometrial tissue outside of the uterine wall. Glutathione S- transferase (GSTs) is a key enzyme in phase I and II that catalyzes the conjugation of glutathione to genotoxic compounds. Glutathione S- transferase M1 (GSTM1) is a versatile enzyme that plays an important role in detoxification of carcinogenic metabolites. The aim of this study was to evaluate serum levels GSTM1 in patients with endometriosis. In this study, blood samples from 20 women with endometriosis and 20 healthy women were collected. The final concentration of protein in the blood of patients (TPC) and GSTM1 in serum by using "biuret" and enzyme-linked immunosorbent assay "(ELISA) were measured. It was shown that the level of total protein concentration all samples are within the normal range and no significant changes between the two groups were seen. Although significant reduction in serum levels GSTM1 was observed in patients with Endometriosis compared to the control group (P = 0.002). The results of this study showed that GSTM1 is involved pathophysiology of endometriosis. - Full Text: PDF - DOI:10.5539/jmbr.v6n1p67 Index Contact - Grace BrownEditorial Assistant - [email protected]

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endometriosis

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