Glutathione S-transferase M1 gene polymorphism and susceptibility to endometriosis in a French population

В. С. Баранов, Baranova H, H. Baranova, Bothorishvilli R, R. Bothorishvilli, Canis M, M Canis, Albuisson E, E Albuisson, Perriot S, S Perriot, Glowaczower E, E Glowaczower, M A Bruhat, Bruhat MA, Baranov V, V Baranov, Malet P, P Malet
Molecular human reproduction · 1997 · vol. 3(9) , pp. 775–780 · doi:10.1093/molehr/3.9.775 · PMID:9358003 · W2119545073
article OA: bronze CC0 ⤵ 80 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study found that a high frequency of the GSTM1 null genotype, lacking enzyme activity, was associated with endometriosis in a French population compared to controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a multifactorial disease with possible genetic predisposition and involvement of environmental factors in its pathogenesis. The genetic polymorphism of glutathione S-transferase M1 (GSTM1) gene, which codes for glutathione S-transferase 1, class mu foreign compound conjugating enzyme of phase II detoxification system, was studied by polymerase chain reaction from the blood spots in patients with different stages of endometriosis (n = 50) and in controls (n = 72) of French origin. A total of 86.0% of patients appeared to lack GSTM1 enzyme activity due to the presence of an extended deletion (GSTM1 0/0 genotype), compared with 45.8% in a control group (P < 0.0001), which was consistent with the frequency of GSTM1 deletion in French population. Moreover, the distribution of GSTM1-active genotypes was significantly different in patients and controls (P < 0.0001), as no patient with GSTM1A/B genotype, which is correlated with the highest activity of GSTM1 enzyme, has been found so far (18.1% in a control group). The unusually high frequency of homozygotes for the GSTM1 gene deletion among patients with endometriosis suggests a possible contribution of environmental toxins in the pathogenesis of this disease due to the absence or low activity of GSTM1 enzyme.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Genes Glutathione Transferase Adolescent Adult Alleles Endometriosis Female France France Gene Frequency Genetic Predisposition to Disease Genotype Glutathione Transferase Glutathione Transferase Humans Middle Aged Polymerase Chain Reaction Polymerase Chain Reaction

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

Cited by (50)

Source provenance

europepmc
last seen: 2026-09-21T06:08:07.822426+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:10:46.468712+00:00
License: CC0 · commercial use OK