Polymorphism of the Interleukin-1β Gene and Endometriosis

F Wieser, Wieser F, Friedrich Wieser, Fritz Wieser, Lukas Hefler, Hefler L, Clemens Tempfer, Tempfer C, Vlach U, Ulli Vlach, Christian Schneeberger, Schneeberger C, Huber J, Johannes Huber, Rene Wenzl, Wenzl R
Journal of the Society for Gynecologic Investigation · 2003 · vol. 10(3) , pp. 172–175 · doi:10.1016/s1071-5576(03)00006-6 · PMID:12699881 · W2000614523
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This study investigated the association between variations in the Interleukin-1β gene and the occurrence of endometriosis.

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Abstract

ObjectiveExperimental data indicate that interleukin (IL)-1 plays a role in the pathogenesis of endometriosis. We determined the genotype and the allele frequencies of the IL1B exon 5 polymorphism and the corresponding IL-1beta serum levels in women with endometriosis.MethodsWe genotyped 92 women with surgically and histologically confirmed endometriosis and 69 controls without history of endometriosis. Both groups were of middle European genetic background for the IL1B exon 5 polymorphism (at position +3954). Genotyping was performed by pyrosequencing. IL-1beta serum levels were analyzed by a commercially available enzyme-linked immunosorbent assay.ResultsAllele frequencies in women with endometriosis and controls were 76.6% and 76.8%, respectively, for the E1 allele (wild type) and 23.4% and 23.2%, respectively, for the E2 allele (polymorphic) (odds ratio 1.01; P > .99). The investigated polymorphism of the IL-1beta gene was not correlated with IL-1beta serum levels.ConclusionsWe did not find an association between the IL1B exon 5 polymorphism, endometriosis, or increased serum IL-1beta levels.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin-1 Polymorphism, Genetic Alleles Endometriosis Exons Female Gene Frequency Genotype Humans Interleukin-1 Interleukin-1

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