A functional promoter polymorphism in interleukin-10 gene influences susceptibility to endometriosis

Suh‐Hang Hank Juo, Suh-Hang Hank Juo, Juo SH, R. Wu, Rita Wu, Wu R, Chang-Shen Lin, Chang‐Shen Lin, Wu MT, Ming‐Tsang Wu, Ming-Tsang Wu, Lee JN, Jau-Nan Lee, Eing-Mei Tsai, Eing‐Mei Tsai, Tsai EM
Fertility and sterility · 2008 · vol. 92(4) , pp. 1228–1233 · doi:10.1016/j.fertnstert.2008.08.015 · PMID:18930197 · W2150437965
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated how a specific genetic variation in the interleukin-10 gene's promoter region affects an individual's likelihood of developing endometriosis.

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Abstract

ObjectiveTo investigate the involvement of inflammation in the development of endometriosis.DesignCase-control study to investigate the association between endometriosis and four inflammation-related genes: interleukin (IL)-6, IL-10, IL-1 beta, and cyclooxygenase-2.SettingUniversity hospital.Patient(s)We had 196 cases with pathologically proved endometriosis and 397 disease-free women as control subjects.Intervention(s)A total of 12 single nucleotide polymorphisms (SNPs) were selected for genotyping, including functional SNPs and common tagging SNPs.Main outcome measure(s)Logistic regression and haplotype analyses were performed to evaluate the genetic effect with adjustment for other covariates.Result(s)Genotypes at each SNP were in Hardy-Weinberg equilibrium in either case or control subjects, except for rs1800871 at IL-10 in the case subjects (P=.04). We found that the individuals carrying minor allele C of a functional promoter SNP rs1800871 at IL-10 was associated with a reduced risk by approximately twofold compared with the common TT genotype. The T allele was reported to have a lower gene expression level than the C allele, suggesting inadequate suppression of inflammation leading to endometriosis development. Haplotype analysis of the IL-10 gene did not yield a better result. Other genes were not associated with endometriosis.Conclusion(s)This study suggests that the functional promoter polymorphism at IL-10 may play a role in the development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin-10 Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Promoter Regions, Genetic Promoter Regions, Genetic Uterine Diseases Adult Case-Control Studies Endometriosis Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Interleukin-10 Linkage Disequilibrium Middle Aged Uterine Diseases

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References (38)

Cited by (25)

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