A functional promoter polymorphism in interleukin-10 gene influences susceptibility to endometriosis

Suh‐Hang Hank Juo, Suh-Hang Hank Juo, Juo SH, R. Wu, Rita Wu, Wu R, Chang-Shen Lin, Chang‐Shen Lin, Wu MT, Ming‐Tsang Wu, Ming-Tsang Wu, Lee JN, Jau-Nan Lee, Eing-Mei Tsai, Eing‐Mei Tsai, Tsai EM
Fertility and sterility · 2008 · vol. 92(4) , pp. 1228–1233 · doi:10.1016/j.fertnstert.2008.08.015 · PMID:18930197 · W2150437965
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This study investigated how a specific genetic variation in the interleukin-10 gene's promoter region affects an individual's likelihood of developing endometriosis.

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Abstract

OBJECTIVE: To investigate the involvement of inflammation in the development of endometriosis. DESIGN: Case-control study to investigate the association between endometriosis and four inflammation-related genes: interleukin (IL)-6, IL-10, IL-1 beta, and cyclooxygenase-2. SETTING: University hospital. PATIENT(S): We had 196 cases with pathologically proved endometriosis and 397 disease-free women as control subjects. INTERVENTION(S): A total of 12 single nucleotide polymorphisms (SNPs) were selected for genotyping, including functional SNPs and common tagging SNPs. MAIN OUTCOME MEASURE(S): Logistic regression and haplotype analyses were performed to evaluate the genetic effect with adjustment for other covariates. RESULT(S): Genotypes at each SNP were in Hardy-Weinberg equilibrium in either case or control subjects, except for rs1800871 at IL-10 in the case subjects (P=.04). We found that the individuals carrying minor allele C of a functional promoter SNP rs1800871 at IL-10 was associated with a reduced risk by approximately twofold compared with the common TT genotype. The T allele was reported to have a lower gene expression level than the C allele, suggesting inadequate suppression of inflammation leading to endometriosis development. Haplotype analysis of the IL-10 gene did not yield a better result. Other genes were not associated with endometriosis. CONCLUSION(S): This study suggests that the functional promoter polymorphism at IL-10 may play a role in the development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin-10 Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Promoter Regions, Genetic Promoter Regions, Genetic Promoter Regions, Genetic Uterine Diseases Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Genetic Predisposition to Disease

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (38)

Cited by (25)

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