T‐cell receptor beta polymorphism is not associated with endometriosis

Pasquale Tripputi, P. Tripputi, Monica Bignotto, B. Monica, Daniela Cigognini, Stefano Bianchi, Luigi Fedele
Journal of Obstetrics and Gynaecology Research · 2011 · vol. 37(10) , pp. 1405–1408 · doi:10.1111/j.1447-0756.2011.01551.x · PMID:21599810 · W1550339961
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This study found no significant association between the TCRB rs1800907 single nucleotide polymorphism and endometriosis in an Italian population.

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Abstract

AIM: We carried out an association study between T-cell receptor beta polymorphism (TCRB) and endometriosis to investigate the difference in allelic frequency. Polymorphisms in T-cell receptor genes can provide important information for the study of the immune response and autoimmune diseases; indeed, rs1800907, a very common single nucleotide polymorphism (SNP) of the TCRB, has been extensively studied in autoimmune diseases in the 1990s using Southern blot analysis and more recently polymerase chain reaction (PCR) and sequencing. An autoimmune etiology for endometriosis has been strongly suggested for the presence of antibodies against endometrium, high rates of autoimmune disorders and associated atopic diseases. MATERIAL AND METHODS: We investigated 70 patients with endometriosis and 120 controls. DNA of patients and controls was studied by PCR followed by restriction digestion and sequencing to determine genotype and presence of linkage disequilibrium (LD). Statistical analysis was carried out using STATA Routine GENHW (StataCorp, College Station, TX, USA) for estimation of Hardy-Weinberg equilibrium and test power calculation. The difference of allele distribution between patients and controls was calculated according to Pearson's and Fisher's tests. Test power for the estimation of linkage disequilibrium is low (0.16). RESULTS: We performed an association study of the SNP rs1800907 of TCRB between 70 patients with endometriosis and 120 controls, and did not find any significant difference (χ(2) = 0.27 and P = 0.87). Fisher's test confirmed a P-value of 0.872. CONCLUSION: Our study does not suggest an evidential and major involvement of TCRB in the pathogenesis of endometriosis in an Italian population in a small case control study.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Genes, T-Cell Receptor beta Polymorphism, Single Nucleotide Receptors, Antigen, T-Cell, alpha-beta Adult Alleles Case-Control Studies Endometriosis Female Gene Frequency Genes, T-Cell Receptor beta Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Italy Linkage Disequilibrium Middle Aged Receptors, Antigen, T-Cell, alpha-beta

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