Interleukin-1β induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian endometrioma

Kao AP, An‐Pei Kao, An-Pei Kao, Wang KH, Kai-Hung Wang, Kai‐Hung Wang, Cheng-Yu Long, Cheng‐Yu Long, Long CY, Chee-Yin Chai, Chee‐Yin Chai, Cheng‐Fang Tsai, Tsai CF, Cheng-Fang Tsai, Tsung-Hua Hsieh, Tsung‐Hua Hsieh, Hsieh TH, Chia‐Yi Hsu, Chia-Yi Hsu, Chang CC, Chia-Cheng Chang, Chia‐Cheng Chang, Lee JN, Jau-Nan Lee, Eing-Mei Tsai, Tsai EM, Eing‐Mei Tsai
Fertility and sterility · 2011 · vol. 96(3) , pp. 678–684.e1 · doi:10.1016/j.fertnstert.2011.06.041 · PMID:21762900 · W2029933078
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Interleukin-1β was found to increase cyclooxygenase-2 expression and enhance the invasive potential of human mesenchymal stem cells originating from ovarian endometriomas.

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Abstract

ObjectiveTo elucidate the role of interleukin-1β (IL-1β) on cyclooxygenase-2 (COX-2) expression and invasion of endometrioma-derived ectopic endometrial mesenchymal stem cells (EN-MSCs) and to develop an organoid method to study the invasive ability of endometrial cells.DesignGene expression and cell functions.SettingKaohsiung Medical University, Kaohsiung, Taiwan.Patient(s)Human eutopic and endometrioma-derived ectopic EN-MSCs were isolated from different endometrium biopsy samples after surgery for treatment of endometriosis.Intervention(s)Chemical treatment of cell culture.Main outcome measure(s)Comparative analysis of genomewide messenger RNA (mRNA) expression, cell migration, and invasion abilities in cell culture and organoid culture.Result(s)Gene expression profiles revealed that the expression of IL-1β and COX-2 were statistically significantly higher in ectopic EN-MSCs compared with eutopic EN-MSCs. These enhanced expressions coincided with a greater ability for cell migration and invasion in ectopic EN-MSCs and were found to be distinctly regulated by IL-1β which up-regulates COX-2 expression. Furthermore, IL-1β treatment of ectopic EN-MSCs in organoids was found to induce tentacle-like structures that mimicked cell invasion.Conclusion(s)These results indicate that COX-2 and IL-1β regulate the invasion ability of ectopic EN-MSCs. The information may be useful for developing a new therapeutic strategy for endometriosis. The ex vivo invasion model will be useful for characterization of EN-MSCs.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Cyclooxygenase 2 Endometriosis Endometrium Interleukin-1beta Mesenchymal Stem Cells Biopsy Cell Movement Cell Movement Cells, Cultured Cyclooxygenase 2 Cyclooxygenase 2 Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Gene Expression Profiling Gene Expression Regulation, Enzymologic Gene Expression Regulation, Enzymologic

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