Celecoxib attenuates interleukin 33-induced expression of vascular cell adhesion molecule-1 in human ovarian endometriotic stromal cells

Ta-Chin Lin, Kai-Hung Wang, Kai‐Hung Wang, Kuo‐Hsiang Chuang, Kuo-Hsiang Chuang, An-Pei Kao, An‐Pei Kao, Tsung-Cheng Kuo, Tsung‐Cheng Kuo
Taiwanese journal of obstetrics & gynecology · 2024 · vol. 63(2) , pp. 178–185 · doi:10.1016/j.tjog.2024.01.012 · PMID:38485312 · W4392691659
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Interleukin 33 induces vascular cell adhesion molecule-1 expression in ovarian endometriotic stromal cells via the IL-33/ST2/MAPK/COX-2 pathway, which celecoxib attenuates.

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Abstract

OBJECTIVE: Endometriosis is an estrogen-dependent chronic inflammatory disease in women of reproductive age. A review of the literature revealed that cytokines and inflammatory factors are associated with endometriosis-associated infertility. Interleukin 33 (IL-33) is a strong inducer of other pro-inflammatory cytokines. Vascular cell adhesion molecule-1 (VCAM-1) plays a central role in recruiting inflammatory cells, whose expression facilitates leukocyte adhesion and is rapidly induced by pro-inflammatory cytokines. Many studies have indicated that VCAM-1 expression is high in endometriosis; however, whether the expression of VCAM-1 is related to IL-33 is unclear. MATERIALS AND METHODS: Human ovarian endometriotic stromal cells (hOVEN-SCs) were treated with IL-33 to enable investigation of cell characterization, gene and protein expression, and signal pathways. Proliferation potential was measured using an MTT assay. Gene expression was analyzed using reverse transcription-polymerase chain reaction. Protein expression assay was performed using western blot analysis. RESULTS: This study investigated the effects of IL-33 on VCAM-1 and COX-2 expression in hOVEN-SCs. First, the results revealed that the IL-33/ST2/mitogen-activated protein kinase (MAPK) signaling pathway could increase the expression of VCAM-1 and COX-2 in hOVEN-SCs. Second, we discovered that COX-2 expression was essential for IL-33-induced VCAM-1 expression because the effects could be negated through NS398, a selective COX-2 inhibitor. Finally, treatment of IL-33-treated hOVEN-SCs with celecoxib significantly and dose-responsively decreased VCAM-1 expression. CONCLUSION: Taken together, these results indicate that IL-33 can upregulate VCAM-1 expression in hOVEN-SCs through the IL-33/ST2/MAPK/COX-2 signaling pathway and thereby contribute to endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1

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