Molecular and Cellular Changes in the Pathogenesis of Endometriosis

The review examines molecular and cell changes in the pathogenesis of endometriosis. Literature data on innate and adaptative immunity are presented, the role of changes in the hormonal status and nuclear receptors for steroid hormones is considered, and a possible epithelial–mesenchymal transition in endometrial cells and at the site of their attachment during the formation of an ectopic focus of endometrium is discussed. The role of the combined action of various factors in the pathogenesis of endometriosis is discussed. Similar content being viewed by others

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Genes linked to endometriosis by GWAS are integral to cytoskeleton regulation and suggests that mesothelial barrier homeostasis is a factor in the pathogenesis of endometriosis, Reprod. Sci., 2017, vol. 24, no. 6, p. 803. ACKNOWLEDGMENTS The authors are grateful to Maria Alexandrovna Usik for invaluable assistance in preparing the review. Funding This work was supported by Basic Research Program no. 65.4 of the Institute of Biomedical Problems, Russian Academy of Sciences (Moscow), and the Strategic Academic Leadership Program (Sechenov University, Moscow). Author information Authors and Affiliations Corresponding authors Ethics declarations COMPLIANCE WITH ETHICAL STANDARDS This article does not contain any studies involving animals or human participants performed by any of the authors. CONFLICT OF INTEREST The authors declare that they have no conflict of interests. Additional information Translated by E. Babchenko Rights and permissions About this article Cite this article Toniyan, K.A., Orlov, O.I., Boyarintsev, V.V. et al. Molecular and Cellular Changes in the Pathogenesis of Endometriosis. Hum Physiol 47, 690–699 (2021). https://doi.org/10.1134/S0362119721060116 Received: Revised: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1134/S0362119721060116